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Assessing Risk in Patients with Stable Coronary Disease: When Should We Intensify Care and Follow-Up? Results from a Meta-Analysis of Observational Studies of the COURAGE and FAME Era
Joint Authors
D’Ascenzo, Fabrizio
Biondi-Zoccai, G.
Barbero, Umberto
Nijhoff, Freek
Moretti, Claudio
Mennuni, Marco
Capodanno, Davide
Lococo, Marco
Lipinski, Michael J.
Gaita, Fiorenzo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
A large number of clinical and laboratory markers have been appraised to predict prognosis in patients with stable angina, but uncertainty remains regarding which variables are the best predictors of prognosis.
Therefore, we performed a meta-analysis of studies in patients with stable angina to assess which variables predict prognosis.
Methods.
MEDLINE and PubMed were searched for eligible studies published up to 2015, reporting multivariate predictors of major adverse cardiac events (MACE, a composite endpoint of death, myocardial infarction, and revascularization) in patients with stable angina.
Study features, patient characteristics, and prevalence and predictors of such events were abstracted and pooled with random-effect methods (95% CIs).
Major adverse cardiovascular event (MACE) was the primary endpoint.
Results.
42 studies (104,559 patients) were included.
After a median follow-up of 57 months, cardiovascular events occurred in 7.8% of patients with MI in 6.2% of patients and need for repeat revascularization (both surgical and percutaneous) in 19.5% of patients.
Male sex, reduced EF, diabetes, prior MI, and high C-reactive protein were the most powerful predictors of cardiovascular events.
Conclusions.
We show that simple and low-cost clinical features may help clinicians in identifying the most appropriate diagnostic and therapeutic approaches within the broad range of outpatients presenting with stable coronary artery disease.
American Psychological Association (APA)
Barbero, Umberto& D’Ascenzo, Fabrizio& Nijhoff, Freek& Moretti, Claudio& Biondi-Zoccai, G.& Mennuni, Marco…[et al.]. 2016. Assessing Risk in Patients with Stable Coronary Disease: When Should We Intensify Care and Follow-Up? Results from a Meta-Analysis of Observational Studies of the COURAGE and FAME Era. Scientifica،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117644
Modern Language Association (MLA)
Barbero, Umberto…[et al.]. Assessing Risk in Patients with Stable Coronary Disease: When Should We Intensify Care and Follow-Up? Results from a Meta-Analysis of Observational Studies of the COURAGE and FAME Era. Scientifica No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1117644
American Medical Association (AMA)
Barbero, Umberto& D’Ascenzo, Fabrizio& Nijhoff, Freek& Moretti, Claudio& Biondi-Zoccai, G.& Mennuni, Marco…[et al.]. Assessing Risk in Patients with Stable Coronary Disease: When Should We Intensify Care and Follow-Up? Results from a Meta-Analysis of Observational Studies of the COURAGE and FAME Era. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117644