Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats
Joint Authors
Talebi, Ardeshir
Mirsaeedi, Fatemeh Sadat
Ahmadian, Sarina
Moslemi, Fatemeh
Eshraghi-Jazi, Fatemeh
Nematbakhsh, Mehdi
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Gentamicin (GM) induced nephrotoxicity may be sex hormones related.
The effects of sex hormones on GM induced nephrotoxicity in gonadectomized rats were investigated.
Methods.
Ovariectomized rats received 0.25, 0.5, or 1 mg/kg/week of estradiol (ES) alone or accompanied with 10 mg/kg/week of progesterone (Pro) for two weeks followed by GM (100 mg/kg/day) for 9 days.
Castrated rats were also treated with 10, 50, or 100 mg/kg/week of testosterone (TS) for two weeks and then received GM.
In addition, a single castrated group received 0.25 mg/kg/week of ES plus GM.
Results.
GM increased the serum levels of blood urea nitrogen (BUN) and creatinine (Cr) and kidney tissue damage score (KTDS) ( P < 0.05 ).
TS had no effect on the serum levels of BUN and Cr and KTDS, while low dose of ES intensified these parameters in male ( P < 0.05 ).
ES (0.5 mg/kg) without Pro ameliorated KTDS in female ( P < 0.05 ) while ES (1 mg/kg) with or without Pro exacerbated the BUN values and Cr values, KTDS, and body weight loss ( P < 0.05 ).
Conclusion.
ES (0.5 mg/kg) without Pro ameliorated kidney damage induced by GM in female while neither TS nor ES had beneficial effect on nephrotoxicity induced by GM in male, although ES aggravated it.
American Psychological Association (APA)
Eshraghi-Jazi, Fatemeh& Talebi, Ardeshir& Mirsaeedi, Fatemeh Sadat& Ahmadian, Sarina& Moslemi, Fatemeh& Nematbakhsh, Mehdi. 2016. Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats. Scientifica،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117736
Modern Language Association (MLA)
Eshraghi-Jazi, Fatemeh…[et al.]. Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats. Scientifica No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1117736
American Medical Association (AMA)
Eshraghi-Jazi, Fatemeh& Talebi, Ardeshir& Mirsaeedi, Fatemeh Sadat& Ahmadian, Sarina& Moslemi, Fatemeh& Nematbakhsh, Mehdi. Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117736