The Rising Era of Immune Checkpoint Inhibitors in Myelodysplastic Syndromes
Joint Authors
Chokr, Nora
Patel, Rima
Wattamwar, Kapil
Chokr, Samer
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by ineffective hematopoiesis and a wide spectrum of manifestations ranging from indolent and asymptomatic cytopenias to acute myeloid leukemia (AML).
MDS result from genetic and epigenetic derangements in clonal cells and their surrounding microenvironments.
Studies have shown associations between MDS and other autoimmune diseases.
Several immune mechanisms have been identified in MDS, suggesting that immune dysregulation might be at least partially implicated in its pathogenesis.
This has led to rigorous investigations on the role of immunomodulatory drugs as potential treatment options.
Epigenetic modification via immune check point inhibition, while well established as a treatment method for advanced solid tumors, is a new approach being considered in hematologic malignancies including high risk MDS.
Several trials are looking at the efficacy of these agents in MDS, as frontline therapy and in relapse, both as monotherapy and in combination with other drugs.
In this review, we explore the utility of immune checkpoint inhibitors in MDS and current research evaluating their efficacy.
American Psychological Association (APA)
Chokr, Nora& Patel, Rima& Wattamwar, Kapil& Chokr, Samer. 2018. The Rising Era of Immune Checkpoint Inhibitors in Myelodysplastic Syndromes. Advances in Hematology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1117737
Modern Language Association (MLA)
Chokr, Nora…[et al.]. The Rising Era of Immune Checkpoint Inhibitors in Myelodysplastic Syndromes. Advances in Hematology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1117737
American Medical Association (AMA)
Chokr, Nora& Patel, Rima& Wattamwar, Kapil& Chokr, Samer. The Rising Era of Immune Checkpoint Inhibitors in Myelodysplastic Syndromes. Advances in Hematology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1117737
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117737