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A High-Fat, High-Fructose Diet Induces Antioxidant Imbalance and Increases the Risk and Progression of Nonalcoholic Fatty Liver Disease in Mice
Joint Authors
Jarukamjorn, Kanokwan
Jearapong, Nattharat
Pimson, Charinya
Chatuphonprasert, Waranya
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Excessive fat liver is an important manifestation of nonalcoholic fatty liver disease (NAFLD), associated with obesity, insulin resistance, and oxidative stress.
In the present study, the effects of a high-fat, high-fructose diet (HFFD) on mRNA levels and activities of the antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), were determined in mouse livers and brains.
The histomorphology of the livers was examined and the state of nonenzymatic reducing system was evaluated by measuring the glutathione system and the lipid peroxidation.
Histopathology of the liver showed that fat accumulation and inflammation depended on the period of the HFFD-consumption.
The levels of mRNA and enzymatic activities of SOD, CAT, and GPx were raised, followed by the increases in malondialdehyde levels in livers and brains of the HFFD mice.
The oxidized GSSG content was increased while the total GSH and the reduced GSH were decreased, resulting in the increase in the GSH/GSSG ratio in both livers and brains of the HFFD mice.
These observations suggested that liver damage and oxidative stress in the significant organs were generated by continuous HFFD-consumption.
Imbalance of antioxidant condition induced by long-term HFFD-consumption might increase the risk and progression of NAFLD.
American Psychological Association (APA)
Jarukamjorn, Kanokwan& Jearapong, Nattharat& Pimson, Charinya& Chatuphonprasert, Waranya. 2016. A High-Fat, High-Fructose Diet Induces Antioxidant Imbalance and Increases the Risk and Progression of Nonalcoholic Fatty Liver Disease in Mice. Scientifica،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117740
Modern Language Association (MLA)
Jarukamjorn, Kanokwan…[et al.]. A High-Fat, High-Fructose Diet Induces Antioxidant Imbalance and Increases the Risk and Progression of Nonalcoholic Fatty Liver Disease in Mice. Scientifica No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1117740
American Medical Association (AMA)
Jarukamjorn, Kanokwan& Jearapong, Nattharat& Pimson, Charinya& Chatuphonprasert, Waranya. A High-Fat, High-Fructose Diet Induces Antioxidant Imbalance and Increases the Risk and Progression of Nonalcoholic Fatty Liver Disease in Mice. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117740