Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes
Joint Authors
Dudina, Galina A.
Donetskova, Almira D.
Litvina, Marina M.
Mitin, Alexander N.
Mitina, Tatiana A.
Polyakov, Sergey A.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease.
At the same time in untreated patients, we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly due to inflammation.
Based on the already known information about the potentially higher functional activity of FOXP3 molecule lacking exon 2, we have also hypothesized that our finding may explain the high risk of autoimmune disorders in this disease.
American Psychological Association (APA)
Dudina, Galina A.& Donetskova, Almira D.& Litvina, Marina M.& Mitin, Alexander N.& Mitina, Tatiana A.& Polyakov, Sergey A.. 2018. Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes. Advances in Hematology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1117758
Modern Language Association (MLA)
Dudina, Galina A.…[et al.]. Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes. Advances in Hematology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1117758
American Medical Association (AMA)
Dudina, Galina A.& Donetskova, Almira D.& Litvina, Marina M.& Mitin, Alexander N.& Mitina, Tatiana A.& Polyakov, Sergey A.. Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes. Advances in Hematology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1117758
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117758