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GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer
Joint Authors
Xu, Haifeng
Zheng, Yongchang
Shi, Yue
Yu, Si
Han, Yuanyuan
Kang, Kai
Gu, Huajian
Sang, Xinting
Chen, Yang
Wang, Jingyu
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
GTSE1 is well correlated with tumor progression; however, little is known regarding its role in liver cancer prognosis.
By analyzing the hepatocellular carcinoma (HCC) datasets in GEO and TCGA databases, we showed that high expression of GTSE1 was correlated with advanced pathologic stage and poor prognosis of HCC patients.
To investigate underlying molecular mechanism, we generated GTSE1 knockdown HCC cell line and explored the effects of GTSE1 deficiency in cell growth.
Between GTSE1 knockdown and wild-type HCC cells, we identified 979 differentially expressed genes (520 downregulated and 459 upregulated genes) in the analysis of microarray-based gene expression profiling.
Functional enrichment analysis of DEGs suggested that S phase was dysregulated without GTSE1 expression, which was further verified from flow cytometry analysis.
Moreover, three other DEGs: CDC20, PCNA, and MCM6, were also found contributing to GTSE1-related cell cycle arrest and to be associated with poor overall survival of HCC patients.
In conclusion, GTSE1, together with CDC20, PCNA, and MCM6, may synergistically promote adverse prognosis in HCC by activating cell cycle.
Genes like GTSE1, CDC20, PCNA, and MCM6 may be promising prognostic molecular biomarkers in liver cancer.
American Psychological Association (APA)
Zheng, Yongchang& Shi, Yue& Yu, Si& Han, Yuanyuan& Kang, Kai& Xu, Haifeng…[et al.]. 2019. GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1117762
Modern Language Association (MLA)
Zheng, Yongchang…[et al.]. GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer. Analytical Cellular Pathology No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1117762
American Medical Association (AMA)
Zheng, Yongchang& Shi, Yue& Yu, Si& Han, Yuanyuan& Kang, Kai& Xu, Haifeng…[et al.]. GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1117762
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117762