Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma
Joint Authors
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study was to validate changes in the levels of folate receptor-α (FOLR1), dihydrofolate reductase (DHFR), and methionine synthase reductase (MTRR) in the tissue of OC patients.
The expression of FOLR1, DHFR, and MTRR was evaluated in 80 cases of primary OC, 50 cases of benign ovarian tumors, and 30 normal ovarian tissues.
Associations between protein expression and clinicopathological characters were assessed, and diagnostic and prognostic evaluation of FOLR1, DHFR, and MTRR was performed.
Results showed that upregulated FOLR1 and MTRR and downregulated DHFR were detected in OC.
Patients with abnormality of FOLR1, DHFR, and MTRR tend to have a higher percentage of platinum resistance.
Moreover, the areas under receiver operating characteristic curves (AUCs-ROC) for FOLR1, DHFR, and MTRR were 0.723, 0.717, and 0.714, respectively.
The combination of FOLR1, DHFR, and MTRR could produce an area of 0.864 under the receiver-operating characteristic curve in distinguishing platinum-resistant patients from platinum-sensitive patients (P<0.0001).
Correlations were present between the expression of FOLR1, DHFR, and MTRR.
Furthermore, Kaplan-Meier curves indicated that the patients with overexpressed MTRR had a poorer overall survival time compared to those with low expression (P<0.05).
Thus, folate metabolic enzymes could provide a potential promising biomarker for diagnosis platinum-resistant in OC.
American Psychological Association (APA)
Chen, Jia& Li, Li. 2019. Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1117765
Modern Language Association (MLA)
Chen, Jia& Li, Li. Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma. Analytical Cellular Pathology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1117765
American Medical Association (AMA)
Chen, Jia& Li, Li. Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1117765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117765