Broad Spectrum Anti-Quorum Sensing Activity of Tannin-Rich Crude Extracts of Indian Medicinal Plants
Joint Authors
Shukla, Varsha
Bhathena, Zarine
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Quorum sensing (QS) mechanisms have been demonstrated to have significance in expression of pathogenicity in infectious bacteria.
In Gram negative bacteria the autoinducer molecules that mediate QS are acyl homoserine lactones (AHL) and in Gram positive bacteria they are peptides called autoinducing peptides (AIP).
A screening of tannin-rich medicinal plants was attempted to identify extracts that could interrupt the QS mechanisms in both Gram positive and Gram negative bacteria over a wide range of concentrations and therefore potentially be potent agents that could act as broad spectrum QS inhibitors.
Six out of the twelve Indian medicinal plant extracts that were analyzed exhibited anti-QS activity in Chromobacterium violaceum 12472 and in S.
aureus strain with agr:blaZ fusion over a broad range of subinhibitory concentrations, indicating that the extracts contain high concentration of molecules that can interfere with the QS mechanisms mediated by AHL as well as AIP.
American Psychological Association (APA)
Shukla, Varsha& Bhathena, Zarine. 2016. Broad Spectrum Anti-Quorum Sensing Activity of Tannin-Rich Crude Extracts of Indian Medicinal Plants. Scientifica،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1117790
Modern Language Association (MLA)
Shukla, Varsha& Bhathena, Zarine. Broad Spectrum Anti-Quorum Sensing Activity of Tannin-Rich Crude Extracts of Indian Medicinal Plants. Scientifica No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1117790
American Medical Association (AMA)
Shukla, Varsha& Bhathena, Zarine. Broad Spectrum Anti-Quorum Sensing Activity of Tannin-Rich Crude Extracts of Indian Medicinal Plants. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1117790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117790