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SGK1 Mediates Hypoxic Pulmonary Hypertension through Promoting Macrophage Infiltration and Activation
Joint Authors
Du, Jie
Xi, Xin
Zhang, Jing
Wang, Jian
Chen, Yuqin
Zhang, Wenmei
Zhang, Xiaoping
Zhu, Guangfa
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Inflammation plays a pivotal role in the development of pulmonary arterial hypertension (PAH).
Meanwhile, serum glucocorticoid-regulated kinase-1 (SGK1) has been considered to be an important factor in the regulation of inflammation in some vascular disease.
However, the role of SGK1 in hypoxia-induced inflammation and PAH is still unknown.
WT and SGK1-/- mice were exposed to chronic hypoxia to induce PAH.
The quantitative PCR and immunohistochemistry were used to determine the expression of SGK1.
The right ventricular hypertrophy index (RVHI), RV/BW ratio, right ventricle systolic pressure (RVSP), and percentage of muscularised vessels and medical wall thickness were measured to evaluate PAH development.
The infiltration of macrophages and localization of SGK1 on cells were examined by histological analysis.
The effects of SGK1 on macrophage function and cytokine expression were assessed by comparing WT and SGK1-/- macrophages in vitro.
SGK1 has high expression in hypoxia-induced PAH.
Deficiency of SGK1 prevented the development of hypoxia-induced PAH and inhibited macrophage infiltration in the lung.
In addition, SGK1 knockout inhibited the expression of proinflammatory cytokines in macrophages.
SGK1-induced macrophage activation and proinflammatory response contributes to the development of PAH in hypoxia-treated mice.
Thus, SGK1 might be considered a promising target for PAH treatment.
American Psychological Association (APA)
Xi, Xin& Zhang, Jing& Wang, Jian& Chen, Yuqin& Zhang, Wenmei& Zhang, Xiaoping…[et al.]. 2019. SGK1 Mediates Hypoxic Pulmonary Hypertension through Promoting Macrophage Infiltration and Activation. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1117800
Modern Language Association (MLA)
Xi, Xin…[et al.]. SGK1 Mediates Hypoxic Pulmonary Hypertension through Promoting Macrophage Infiltration and Activation. Analytical Cellular Pathology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1117800
American Medical Association (AMA)
Xi, Xin& Zhang, Jing& Wang, Jian& Chen, Yuqin& Zhang, Wenmei& Zhang, Xiaoping…[et al.]. SGK1 Mediates Hypoxic Pulmonary Hypertension through Promoting Macrophage Infiltration and Activation. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1117800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117800