Biochemical Characterization of Liver Oil of Echinorhinus brucus (Bramble Shark) and Its Cytotoxic Evaluation on Neuroblastoma Cell Lines (SHSY-5Y)
Joint Authors
Venugopal, Vishnu
Kumaran, Ajeeshkumar Kizhakkepurath
Sekhar Chatterjee, Niladri
Kumar, Suvanish
Kavilakath, Shyni
Nair, Jayarani Ramachandran
Mathew, Suseela
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The objective of the present study was to characterize the liver oil extracted from the deep sea shark, Echinorhinus brucus, caught from Central Indian Ocean and to evaluate its cytotoxic effect on neuroblastoma cell line (SHSY-5Y).
Characterization of liver oil of Echinorhinus brucus revealed the presence of palmitic acid (15%), oleic acid (12%), stearic acid (8%), docosahexaenoic acid (DHA) (18%), and eicosapentaenoic acid (EPA) (16%).
It was also found to be a good source of squalene (38.5%) and fat soluble vitamins such as A, D, and K (vitamin A: 17.08 mg/100 g of oil, vitamin D: 15.04 mg/100 g oil, and vitamin K: 11.45 mg/100 g oil).
Since it was found to be rich in essential fatty acids, fat soluble vitamins, and squalene, it can be considered as better dietary supplement.
The oil of Echinorhinus brucus also showed high in vitro cytotoxic effect against the human neuroblastoma cell line (SHSY-5Y) and the IC50 value laid between 35 and 45 ng.
American Psychological Association (APA)
Venugopal, Vishnu& Kumaran, Ajeeshkumar Kizhakkepurath& Sekhar Chatterjee, Niladri& Kumar, Suvanish& Kavilakath, Shyni& Nair, Jayarani Ramachandran…[et al.]. 2016. Biochemical Characterization of Liver Oil of Echinorhinus brucus (Bramble Shark) and Its Cytotoxic Evaluation on Neuroblastoma Cell Lines (SHSY-5Y). Scientifica،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1117814
Modern Language Association (MLA)
Venugopal, Vishnu…[et al.]. Biochemical Characterization of Liver Oil of Echinorhinus brucus (Bramble Shark) and Its Cytotoxic Evaluation on Neuroblastoma Cell Lines (SHSY-5Y). Scientifica No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1117814
American Medical Association (AMA)
Venugopal, Vishnu& Kumaran, Ajeeshkumar Kizhakkepurath& Sekhar Chatterjee, Niladri& Kumar, Suvanish& Kavilakath, Shyni& Nair, Jayarani Ramachandran…[et al.]. Biochemical Characterization of Liver Oil of Echinorhinus brucus (Bramble Shark) and Its Cytotoxic Evaluation on Neuroblastoma Cell Lines (SHSY-5Y). Scientifica. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1117814
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117814