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Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology
Joint Authors
Căruntu, Constantin
Bostan, Marinela
Ignat, Simona Rebeca
Constantin, Carolina
Dinescu, Sorina
Marieta, Costache
Neagu, Monica
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-29
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The epithelial-mesenchymal transition (EMT) is a complex transformation process that induces local and distant progression of many malignant tumours.
Due to its complex array of proteins that are dynamically over-/underexpressed during this process, proteomic technologies gained their place in the EMT research in the last years.
Proteomics has identified new molecular pathways of this process and brought important insights to develop new therapy targets.
Various proteomic tools and multiple combinations were developed in this area.
Out of the proteomic technology armentarium, mass spectrometry and array technologies are the most used approaches.
The main characteristics of the proteomic technology used in this domain are high throughput and detection of minute concentration in small samples.
We present herein, using various proteomic technologies, the identification in cancer cell lines and in tumour tissue EMT-related proteins, proteins that are involved in the activation of different cellular pathways.
Proteomics has brought besides standard EMT markers (e.g., cell-cell adhesion proteins and transcription factors) other future potential markers for improving diagnosis, monitoring evolution, and developing new therapy targets.
Future will increase the proteomic role in clinical investigation and validation of EMT-related biomarkers.
American Psychological Association (APA)
Neagu, Monica& Constantin, Carolina& Bostan, Marinela& Căruntu, Constantin& Ignat, Simona Rebeca& Dinescu, Sorina…[et al.]. 2019. Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1117815
Modern Language Association (MLA)
Neagu, Monica…[et al.]. Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology. Analytical Cellular Pathology No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1117815
American Medical Association (AMA)
Neagu, Monica& Constantin, Carolina& Bostan, Marinela& Căruntu, Constantin& Ignat, Simona Rebeca& Dinescu, Sorina…[et al.]. Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1117815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117815