Regulation of Dopamine Uptake by Vasoactive Peptides in the Kidney
Joint Authors
Choi, Marcelo Roberto
Rouvier, E.
Gironacci, M. M.
Kouyoumdzian, Nicolás Martín
Toblli, Jorge Eduardo
Rukavina Mikusic, Natalia Lucía
Fernández, Belisario Enrique
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Considering the key role of renal dopamine in tubular sodium handling, we hypothesized that c-type natriuretic peptide (CNP) and Ang-(1-7) may regulate renal dopamine availability in tubular cells, contributing to Na+, K+-ATPase inhibition.
Present results show that CNP did not affect either 3H-dopamine uptake in renal tissue or Na+, K+-ATPase activity; meanwhile, Ang-(1-7) was able to increase 3H-dopamine uptake and decreased Na+, K+-ATPase activity in renal cortex.
Ang-(1-7) and dopamine together decreased further Na+, K+-ATPase activity showing an additive effect on the sodium pump.
In addition, hydrocortisone reversed Ang-(1-7)-dopamine overinhibition on the enzyme, suggesting that this inhibition is closely related to Ang-(1-7) stimulation on renal dopamine uptake.
Both anantin and cANP (4-23-amide) did not modify CNP effects on 3H-dopamine uptake by tubular cells.
The Mas receptor antagonist, A-779, blocked the increase elicited by Ang-(1-7) on 3H-dopamine uptake.
The stimulatory uptake induced by Ang-(1-7) was even more pronounced in the presence of losartan, suggesting an inhibitory effect of Ang-(1-7) on AT1 receptors on 3H-dopamine uptake.
By increasing dopamine bioavailability in tubular cells, Ang-(1-7) enhances Na+, K+-ATPase activity inhibition, contributing to its natriuretic and diuretic effects.
American Psychological Association (APA)
Rukavina Mikusic, Natalia Lucía& Kouyoumdzian, Nicolás Martín& Rouvier, E.& Gironacci, M. M.& Toblli, Jorge Eduardo& Fernández, Belisario Enrique…[et al.]. 2016. Regulation of Dopamine Uptake by Vasoactive Peptides in the Kidney. Scientifica،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117816
Modern Language Association (MLA)
Rukavina Mikusic, Natalia Lucía…[et al.]. Regulation of Dopamine Uptake by Vasoactive Peptides in the Kidney. Scientifica No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1117816
American Medical Association (AMA)
Rukavina Mikusic, Natalia Lucía& Kouyoumdzian, Nicolás Martín& Rouvier, E.& Gironacci, M. M.& Toblli, Jorge Eduardo& Fernández, Belisario Enrique…[et al.]. Regulation of Dopamine Uptake by Vasoactive Peptides in the Kidney. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117816