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Epithelial-Mesenchymal Transition in Skin Cancers: A Review
Joint Authors
Popp, Cristiana
Nichita, Luciana
Turcu, Gabriela
Nedelcu, Roxana Ioana
Ion, Daniela Adriana
Cioplea, Mirela
Hodorogea, Anastasia
Calinescu, Andreea
Antohe, Mihaela
Balaban, Mihaela
Badarau, Ioana Anca
Popescu, Catalin Mihai
Popescu, Raluca
Hulea, Ionela
Brinzea, Alice
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Epithelial-mesenchymal transition (EMT) is involved in physiologic processes such as embryogenesis and wound healing.
A similar mechanism occurs in some tumors where cells leave the epithelial layer and gain mesenchymal particularities in order to easily migrate to other tissues.
This process can explain the invasiveness and aggressiveness of these tumors which metastasize, by losing the epithelial phenotype (loss of E-cadherin, desmoplakin, and laminin-1) and acquiring mesenchymal markers (N-cadherin).
Complex changes and interactions happen between the tumor cells and the microenvironment involving different pathways, transcription factors, altered expression of adhesion molecules, reorganization of cytoskeletal proteins, production of ECM-degrading enzymes, and changes in specific microRNAs.
The purpose of this review is to determine particularities of the EMT process in the most common malignant cutaneous tumors (squamous cell carcinoma, basal cell carcinoma, and melanoma) which still have an increasingly high incidence.
More studies are required on this topic in order to establish clear correlations.
High costs related to skin cancer therapies in general as well as high impact on patients’ quality of life demand finding new, reliable prognostic and therapeutic markers with significant public health impact.
American Psychological Association (APA)
Hodorogea, Anastasia& Calinescu, Andreea& Antohe, Mihaela& Balaban, Mihaela& Nedelcu, Roxana Ioana& Turcu, Gabriela…[et al.]. 2019. Epithelial-Mesenchymal Transition in Skin Cancers: A Review. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1117822
Modern Language Association (MLA)
Hodorogea, Anastasia…[et al.]. Epithelial-Mesenchymal Transition in Skin Cancers: A Review. Analytical Cellular Pathology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1117822
American Medical Association (AMA)
Hodorogea, Anastasia& Calinescu, Andreea& Antohe, Mihaela& Balaban, Mihaela& Nedelcu, Roxana Ioana& Turcu, Gabriela…[et al.]. Epithelial-Mesenchymal Transition in Skin Cancers: A Review. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1117822
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117822