In Vitro and In Vivo Evaluation of Niosomal Formulation for Controlled Delivery of Clarithromycin
Joint Authors
Shilakari Asthana, Gyati
Asthana, Abhay
Sharma, Parveen Kumar
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study was focused on formulating and evaluating clarithromycin (CLR) containing niosomal formulation for in vitro and in vivo pharmacokinetic behavior.
Niosomal formulations (empty and drug loaded) were prepared by using different ratio of surfactant (various Span grades 20, 40, 60, and 80) and cholesterol by thin film hydration method and were evaluated for in vitro characteristics, stability studies, and in vivo study.
Dicetyl phosphate (DCP) was added to the niosomal formulation.
Various pharmacokinetic parameters were determined from plasma of male SD rats.
Span 60 containing niosomal formulation NC2 (cholesterol to surfactant ratio 1 : 1) displayed highest entrapment efficiency with desired particle size of 4.67 μm.
TEM analyses showed that niosomal formulation was spherical in shape.
Niosomes containing Span 60 displayed higher percentage of drug release after 24 h as compared to other formulations.
NC2 formulation was found to be stable at the end of the study on storage condition.
Various pharmacokinetic parameters, namely, AUC, AUMC, and MRT of niosomal formulation, were found to be 1.5-fold, 4-fold, and 3-fold plain drug, respectively.
The present study suggested that niosomal formulations provide sustained and prolonged delivery of drug with enhance bioavailability.
American Psychological Association (APA)
Shilakari Asthana, Gyati& Sharma, Parveen Kumar& Asthana, Abhay. 2016. In Vitro and In Vivo Evaluation of Niosomal Formulation for Controlled Delivery of Clarithromycin. Scientifica،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117833
Modern Language Association (MLA)
Shilakari Asthana, Gyati…[et al.]. In Vitro and In Vivo Evaluation of Niosomal Formulation for Controlled Delivery of Clarithromycin. Scientifica No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1117833
American Medical Association (AMA)
Shilakari Asthana, Gyati& Sharma, Parveen Kumar& Asthana, Abhay. In Vitro and In Vivo Evaluation of Niosomal Formulation for Controlled Delivery of Clarithromycin. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117833