Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis
Joint Authors
Popp, Cristiana
Nichita, Luciana
Cioplea, Mirela
Sticlaru, Liana
Stăniceanu, Florica
Cioroianu, Alexandra Ioana
Stinga, Patricia Irina
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diffuse large B-cell lymphoma (DLBCL) represents 30-40% of all non-Hodgkin lymphomas (NHL) and is a disease with an aggressive behavior.
Because about one-third of DLBCL patients will be refractory or resistant to standard therapy, several studies focused on identification of new individual prognostic and risk stratification biomarkers and new potential therapeutic targets.
In contrast to other types of cancers like carcinomas, where tumor microenvironment was widely investigated, its role in DLBCL pathogenesis and patient survival is still poorly understood, although few studies had promising results.
The composition of TME and its interaction with neoplastic cells may explain the role of several genes (beta2-microglobulin gene, CD58 gene), receptor-like programmed cell death-1 (PD-1) and its ligand (PD-L1), or other cell components (Treg) in tumor evasion of immune surveillance, resulting in tumor progression.
Also, it was found that “gene expression profile” of the microenvironmental cells, the phenotype of tumor-associated macrophages (TAM), the expression of matricellular proteins like SPARC and fibronectin, the overexpression of several types of matrix metalloproteinases (MMPs) like MMP-2 and MMP-9, or the tissue inhibitors of matrix metalloproteinases (TIMPs) may lead to a favorable or adverse outcome.
With this review, we try to highlight the influence of microenvironment components over lymphoid clone progression and their prognostic impact in DLBCL patients.
American Psychological Association (APA)
Cioroianu, Alexandra Ioana& Stinga, Patricia Irina& Sticlaru, Liana& Cioplea, Mirela& Nichita, Luciana& Popp, Cristiana…[et al.]. 2019. Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1117896
Modern Language Association (MLA)
Cioroianu, Alexandra Ioana…[et al.]. Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis. Analytical Cellular Pathology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1117896
American Medical Association (AMA)
Cioroianu, Alexandra Ioana& Stinga, Patricia Irina& Sticlaru, Liana& Cioplea, Mirela& Nichita, Luciana& Popp, Cristiana…[et al.]. Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1117896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117896