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Oral Feeding of Probiotic Bifidobacterium infantis: Colonic Morphological Changes in Rat Model of TNBS-Induced Colitis
Joint Authors
Javed, Najma H.
Alsahly, Musaad B.
Khubchandani, Jagdish
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology.
It has been proposed that modifying the bacterial flora in intestine with probiotics may decrease the inflammatory process and prevent relapses in UC.
We investigated the possible protective and therapeutic effects of a single strand of probiotic, Bifidobacterium infantis (BI), on colonic inflammation, in rats with regular feedings.
Two groups of Lewis rats were prepared ( n = 8 ).
The first group was the control, sham-fed group ( n = 4 ).
The other group was the experimental BI-fed group ( n = 4 ).
Colitis was induced in both groups by intrarectal administration of TNBS under light anesthesia.
The sham-fed colitis induced groups received a daily oral gavage feeding of 1.0 mL distilled water, whereas the B.
infantis-fed group received 0.205 g of B.
infantis dissolved in 1.0 mL distilled water daily.
The change in body weight and food and water intake was recorded over the course of each study and analyzed.
The rats were euthanized and tissues from the descending colon were harvested and analyzed microscopically and histologically.
Results of our study indicated significant reduction in inflammation, mucosal damage, and preservation of goblet cells, as compared to the control animals.
Modulation of gastrointestinal (GI) flora suggests a promising field in developing strategies for prevention and treatment of inflammatory bowel diseases by dietary modifications.
American Psychological Association (APA)
Javed, Najma H.& Alsahly, Musaad B.& Khubchandani, Jagdish. 2016. Oral Feeding of Probiotic Bifidobacterium infantis: Colonic Morphological Changes in Rat Model of TNBS-Induced Colitis. Scientifica،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1117999
Modern Language Association (MLA)
Javed, Najma H.…[et al.]. Oral Feeding of Probiotic Bifidobacterium infantis: Colonic Morphological Changes in Rat Model of TNBS-Induced Colitis. Scientifica No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1117999
American Medical Association (AMA)
Javed, Najma H.& Alsahly, Musaad B.& Khubchandani, Jagdish. Oral Feeding of Probiotic Bifidobacterium infantis: Colonic Morphological Changes in Rat Model of TNBS-Induced Colitis. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1117999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117999