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Gene Prioritization by Integrated Analysis of Protein Structural and Network Topological Properties for the Protein-Protein Interaction Network of Neurological Disorders
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neurological disorders are known to show similar phenotypic manifestations like anxiety, depression, and cognitive impairment.
There is a need to identify shared genetic markers and molecular pathways in these diseases, which lead to such comorbid conditions.
Our study aims to prioritize novel genetic markers that might increase the susceptibility of patients affected with one neurological disorder to other diseases with similar manifestations.
Identification of pathways involving common candidate markers will help in the development of improved diagnosis and treatments strategies for patients affected with neurological disorders.
This systems biology study for the first time integratively uses 3D-structural protein interface descriptors and network topological properties that characterize proteins in a neurological protein interaction network, to aid the identification of genes that are previously not known to be shared between these diseases.
Results of protein prioritization by machine learning have identified known as well as new genetic markers which might have direct or indirect involvement in several neurological disorders.
Important gene hubs have also been identified that provide an evidence for shared molecular pathways in the neurological disease network.
American Psychological Association (APA)
Paul, Yashna& Hasija, Yasha. 2016. Gene Prioritization by Integrated Analysis of Protein Structural and Network Topological Properties for the Protein-Protein Interaction Network of Neurological Disorders. Scientifica،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1118003
Modern Language Association (MLA)
Paul, Yashna& Hasija, Yasha. Gene Prioritization by Integrated Analysis of Protein Structural and Network Topological Properties for the Protein-Protein Interaction Network of Neurological Disorders. Scientifica No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1118003
American Medical Association (AMA)
Paul, Yashna& Hasija, Yasha. Gene Prioritization by Integrated Analysis of Protein Structural and Network Topological Properties for the Protein-Protein Interaction Network of Neurological Disorders. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1118003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1118003