Enhancement of Mycophenolate Mofetil Permeation for Topical Use by Eucalyptol and N-Methyl-2-pyrrolidone
Joint Authors
Amnuaikit, Thanaporn
Songkram, Chalermkiat
Pinsuwan, Sirirat
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mycophenolate mofetil (MMF) is a prodrug of mycophenolic acid (MPA) which can be metabolized by esterase.
MMF has been approved by the United States Food and Drug Administration (USFDA) for treatment of psoriasis patient with skin symptoms.
However, it remains unclear whether MMF is efficiently effective to treat skin symptoms developed from psoriasis.
The insufficient amount of MMF penetrating through the skin results in the treatment failure due to the difficulty in MMF penetration through the stratum corneum.
Skin permeation enhancers such as eucalyptol (EUL) and N-methyl-2-pyrrolidone (NMP) potentially aid in increasing skin penetration.
This study aimed to investigate the effects of a concentration ratio (% w/v) between two enhancers (EUL and NMP).
The results showed that EUL enhanced MMF permeation with an enhancement ratio (ER) of 3.44 while NMP was not able to promote the penetration of MMF.
Interestingly, the synergistic effect of the two enhancers was observed with a suitable ratio given that the ER was 8.21.
EUL and NMP are promising enhancers for the development of MMF based skin product.
American Psychological Association (APA)
Amnuaikit, Thanaporn& Songkram, Chalermkiat& Pinsuwan, Sirirat. 2016. Enhancement of Mycophenolate Mofetil Permeation for Topical Use by Eucalyptol and N-Methyl-2-pyrrolidone. Scientifica،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1118012
Modern Language Association (MLA)
Amnuaikit, Thanaporn…[et al.]. Enhancement of Mycophenolate Mofetil Permeation for Topical Use by Eucalyptol and N-Methyl-2-pyrrolidone. Scientifica No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1118012
American Medical Association (AMA)
Amnuaikit, Thanaporn& Songkram, Chalermkiat& Pinsuwan, Sirirat. Enhancement of Mycophenolate Mofetil Permeation for Topical Use by Eucalyptol and N-Methyl-2-pyrrolidone. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1118012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1118012