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Analysis of the Modified Rankin Scale in Randomised Controlled Trials of Acute Ischaemic Stroke: A Systematic Review
Joint Authors
Bath, Philip M. W.
Gray, Laura
Nunn, Aimie
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Historically, most acute stroke clinical trials were neutral statistically, with trials typically dichotomising ordinal scales, such as the modified Rankin Scale.
Studies published before 2007 have shown that preserving the ordinal nature of these scales increased statistical power.
A systematic review of trials published since 2007 was conducted to reevaluate statistical methods used and to assess whether practice has changed.
Methods.
A search of electronic databases identified RCTs published between January 2007 and July 2014 in acute ischaemic stroke using an ordinal dependency scale as the primary outcome.
Findings.
Forty-two RCTs were identified.
The majority used a dichotomous analysis (25, 59.5%), eight (21.4%) retained the ordinal scale, and nine (19.0%) used another type of analysis.
Conclusions.
Trials published since 2007 still favoured dichotomous analyses over ordinal.
Stroke trials, where appropriate, should consider retaining the ordinal nature of dependency scales.
American Psychological Association (APA)
Nunn, Aimie& Bath, Philip M. W.& Gray, Laura. 2016. Analysis of the Modified Rankin Scale in Randomised Controlled Trials of Acute Ischaemic Stroke: A Systematic Review. Stroke Research and Treatment،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1118502
Modern Language Association (MLA)
Nunn, Aimie…[et al.]. Analysis of the Modified Rankin Scale in Randomised Controlled Trials of Acute Ischaemic Stroke: A Systematic Review. Stroke Research and Treatment No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1118502
American Medical Association (AMA)
Nunn, Aimie& Bath, Philip M. W.& Gray, Laura. Analysis of the Modified Rankin Scale in Randomised Controlled Trials of Acute Ischaemic Stroke: A Systematic Review. Stroke Research and Treatment. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1118502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1118502