The Use of Xpert MTBRif for Active Case Finding among TB Contacts in North West Province, South Africa
Joint Authors
Lebina, Limakatso
Fuller, Nigel
Osoba, Tolu
Scott, Lesley
Motlhaoleng, Katlego
Rakgokong, Modiehi
Abraham, Pattamukkil
Variava, Ebrahim
Martinson, Neil Alexander
Source
Tuberculosis Research and Treatment
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Tuberculosis is a major cause of morbidity and mortality especially in high HIV burden settings.
Active case finding is one strategy to potentially reduce TB disease burden.
Xpert MTB/Rif has recently been recommended for diagnosis of TB.
Methods.
Pragmatic randomized trial to compare diagnosis rate and turnaround time for laboratory testing for Xpert MTB/Rif with TB microscopy and culture in household contacts of patients recently diagnosed with TB.
Results.
2464 household contacts enrolled into the study from 768 active TB index cases.
1068 (44%) were unable to give sputum, but 24 of these were already on TB treatment.
863 (53%) participants sputum samples were tested with smear and culture and 2.7% (23/863; CI: 1.62–3.78) were diagnosed with active TB.
Xpert MTB/Rif was used in 515 (21%) participants; active TB was diagnosed in 1.6% (8/515; CI: 0.52–2.68).
Discussion and Conclusions.
Additional 31 cases were diagnosed with contact tracing of household members.
When Xpert MTB/Rif is compared with culture, there is no significant difference in diagnostic yield.
American Psychological Association (APA)
Lebina, Limakatso& Fuller, Nigel& Osoba, Tolu& Scott, Lesley& Motlhaoleng, Katlego& Rakgokong, Modiehi…[et al.]. 2016. The Use of Xpert MTBRif for Active Case Finding among TB Contacts in North West Province, South Africa. Tuberculosis Research and Treatment،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1120256
Modern Language Association (MLA)
Lebina, Limakatso…[et al.]. The Use of Xpert MTBRif for Active Case Finding among TB Contacts in North West Province, South Africa. Tuberculosis Research and Treatment No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1120256
American Medical Association (AMA)
Lebina, Limakatso& Fuller, Nigel& Osoba, Tolu& Scott, Lesley& Motlhaoleng, Katlego& Rakgokong, Modiehi…[et al.]. The Use of Xpert MTBRif for Active Case Finding among TB Contacts in North West Province, South Africa. Tuberculosis Research and Treatment. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1120256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1120256