Effect of Opioid on Adult Hippocampal Neurogenesis

Joint Authors

Zhang, Yue
Loh, Horace H.
Law, Ping-Yee

Source

The Scientific World Journal

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-04-05

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine
Information Technology and Computer Science

Abstract EN

During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed.

Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid.

Here, we review the most recent works on opiate drugs’ effect on different developmental stages of adult hippocampal neurogenesis, as well as the possible underlying mechanisms.

We conclude that opiate drugs in general cause a loss of newly born neural progenitors in the subgranular zone of dentate gyrus, by either modulating proliferation or interfering with differentiation and maturation.

We also discuss the consequent impact of regulation of adult neurogenesis in animal’s opioid addiction behavior.

We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse.

American Psychological Association (APA)

Zhang, Yue& Loh, Horace H.& Law, Ping-Yee. 2016. Effect of Opioid on Adult Hippocampal Neurogenesis. The Scientific World Journal،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1120354

Modern Language Association (MLA)

Zhang, Yue…[et al.]. Effect of Opioid on Adult Hippocampal Neurogenesis. The Scientific World Journal No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1120354

American Medical Association (AMA)

Zhang, Yue& Loh, Horace H.& Law, Ping-Yee. Effect of Opioid on Adult Hippocampal Neurogenesis. The Scientific World Journal. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1120354

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1120354