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Effect of Opioid on Adult Hippocampal Neurogenesis
Joint Authors
Zhang, Yue
Loh, Horace H.
Law, Ping-Yee
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed.
Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid.
Here, we review the most recent works on opiate drugs’ effect on different developmental stages of adult hippocampal neurogenesis, as well as the possible underlying mechanisms.
We conclude that opiate drugs in general cause a loss of newly born neural progenitors in the subgranular zone of dentate gyrus, by either modulating proliferation or interfering with differentiation and maturation.
We also discuss the consequent impact of regulation of adult neurogenesis in animal’s opioid addiction behavior.
We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse.
American Psychological Association (APA)
Zhang, Yue& Loh, Horace H.& Law, Ping-Yee. 2016. Effect of Opioid on Adult Hippocampal Neurogenesis. The Scientific World Journal،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1120354
Modern Language Association (MLA)
Zhang, Yue…[et al.]. Effect of Opioid on Adult Hippocampal Neurogenesis. The Scientific World Journal No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1120354
American Medical Association (AMA)
Zhang, Yue& Loh, Horace H.& Law, Ping-Yee. Effect of Opioid on Adult Hippocampal Neurogenesis. The Scientific World Journal. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1120354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1120354