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Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma
Joint Authors
de Freitas Junior, Wilson Rodrigues
Ilias, Elias Jirjoss
Cordts, Roberto
Malheiros, Carlos Alberto
Kassab, Paulo
Claro, Laura Carolina Lopez
Colombo-Souza, Patrícia
Fukuhara, Daniel Kenji
Thuler, Fábio Rodrigues
Fracassi, Mabel Tatty Medeiros
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Objective.
To evaluate the HER2 expression on gastric adenocarcinoma from a Brazilian population and also to analyze the relations between the receptor and clinical characteristics, as well as the survival status.
Materials and Methods.
A retrospective analysis was conducted from January of 2008 to July of 2012, considering only gastrectomies with curative intent.
Tumors were tested for HER2 status using immunohistochemistry.
The relation between HER2 status and clinical aspects, surgical findings, and survival were also analyzed.
Results.
222 patients with gastric carcinoma were submitted to surgery during that period, but only 121 (54,5%) were with curative intention.
The immunohistochemistry revealed that 4 patients (3,3%) were HER2-positive, 6 patients (4,9%) HER2-undetermined, and 111 patients (91,7%) HER2-negative.
There was no statistical concordance between HER2 status and survival or the clinical aspects.
Conclusion.
The HER2 overexpression rate was very low in this Brazilian population sample and cannot be considered as a prognostic factor.
American Psychological Association (APA)
Cordts, Roberto& Kassab, Paulo& Claro, Laura Carolina Lopez& Fracassi, Mabel Tatty Medeiros& Colombo-Souza, Patrícia& Fukuhara, Daniel Kenji…[et al.]. 2016. Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma. The Scientific World Journal،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1120589
Modern Language Association (MLA)
Cordts, Roberto…[et al.]. Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma. The Scientific World Journal No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1120589
American Medical Association (AMA)
Cordts, Roberto& Kassab, Paulo& Claro, Laura Carolina Lopez& Fracassi, Mabel Tatty Medeiros& Colombo-Souza, Patrícia& Fukuhara, Daniel Kenji…[et al.]. Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma. The Scientific World Journal. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1120589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1120589