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Cell Colonization Ability of a Commercialized Large Porous Alveolar Scaffold
Joint Authors
Lemaire, Thibault
Lemonnier, S.
Bouderlique, T.
Naili, S.
Rouard, H.
Courty, J.
Chevallier, N.
Albanese, P.
Source
Applied Bionics and Biomechanics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The use of filling biomaterials or tissue-engineered large bone implant-coupling biocompatible materials and human bone marrow mesenchymal stromal cells seems to be a promising approach to treat critical-sized bone defects.
However, the cellular seeding onto and into large porous scaffolds still remains challenging since this process highly depends on the porous microstructure.
Indeed, the cells may mainly colonize the periphery of the scaffold, leaving its volume almost free of cells.
In this study, we carry out an in vitro study to analyze the ability of a commercialized scaffold to be in vivo colonized by cells.
We investigate the influence of various physical parameters on the seeding efficiency of a perfusion seeding protocol using large manufactured bone substitutes.
The present study shows that the velocity of the perfusion fluid and the initial cell density seem to impact the seeding results and to have a negative effect on the cellular viability, whereas the duration of the fluid perfusion and the nature of the flow (steady versus pulsed) did not show any influence on either the fraction of seeded cells or the cellular viability rate.
However, the cellular repartition after seeding remains highly heterogeneous.
American Psychological Association (APA)
Lemonnier, S.& Bouderlique, T.& Naili, S.& Rouard, H.& Courty, J.& Chevallier, N.…[et al.]. 2017. Cell Colonization Ability of a Commercialized Large Porous Alveolar Scaffold. Applied Bionics and Biomechanics،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1121162
Modern Language Association (MLA)
Lemonnier, S.…[et al.]. Cell Colonization Ability of a Commercialized Large Porous Alveolar Scaffold. Applied Bionics and Biomechanics No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1121162
American Medical Association (AMA)
Lemonnier, S.& Bouderlique, T.& Naili, S.& Rouard, H.& Courty, J.& Chevallier, N.…[et al.]. Cell Colonization Ability of a Commercialized Large Porous Alveolar Scaffold. Applied Bionics and Biomechanics. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1121162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1121162