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Sevoflurane Ameliorates Myocardial Cell Injury by Inducing Autophagy via the Deacetylation of LC3 by SIRT1
Joint Authors
Fan, Lihua
Chen, Deyuan
Wang, Jianping
Wu, Yini
Li, Dongli
Yu, Xiaoyan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Misfolded and aberrant proteins have been found to be associated with myocardial cell injury.
Thus, increased clearance of misfolded or aggregated proteins via autophagy might be a potential option in preventing myocardial cell injury.
Sevoflurane may ameliorate myocardial cell injury by affecting sirtuin 1- (SIRT1-) mediated autophagy.
Rat models with myocardial cell injury were induced by limb ischemia reperfusion.
The model rats received different treatments: sevoflurane, nicotinamide, and autophagy inhibitor 3-methyladenine (3-MA).
Autophagy was observed by SEM.
The levels of SIRT1 and microtubule-associated protein 1A/1B-light chain 3 (LC3) were measured.
Present findings demonstrated that limb ischemia reperfusion induced autophagy.
Sevoflurane increased the level of SIRT1, which deacetylated LC3 and further increased autophagic rates.
On the other hand, the autophagy was inhibited by sevoflurane and or the inhibitors of SIRT1 and LC3.
Present results demonstrated a novel molecular mechanism by which sevoflurane induced autophagy by increasing the level of SIRT1 and reducing the acetylation of LC3.
American Psychological Association (APA)
Fan, Lihua& Chen, Deyuan& Wang, Jianping& Wu, Yini& Li, Dongli& Yu, Xiaoyan. 2017. Sevoflurane Ameliorates Myocardial Cell Injury by Inducing Autophagy via the Deacetylation of LC3 by SIRT1. Analytical Cellular Pathology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1121714
Modern Language Association (MLA)
Fan, Lihua…[et al.]. Sevoflurane Ameliorates Myocardial Cell Injury by Inducing Autophagy via the Deacetylation of LC3 by SIRT1. Analytical Cellular Pathology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1121714
American Medical Association (AMA)
Fan, Lihua& Chen, Deyuan& Wang, Jianping& Wu, Yini& Li, Dongli& Yu, Xiaoyan. Sevoflurane Ameliorates Myocardial Cell Injury by Inducing Autophagy via the Deacetylation of LC3 by SIRT1. Analytical Cellular Pathology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1121714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1121714