Mesenchymal Stem Cells as New Therapeutic Agents for the Treatment of Primary Biliary Cholangitis
Joint Authors
Arsenijevic, Aleksandar
Harrell, C. Randall
Fellabaum, Crissy
Volarevic, Vladislav
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease characterized by the progressive destruction of small- and medium-sized intrahepatic bile ducts with resultant cholestasis and progressive fibrosis.
Ursodeoxycholic acid and obethicholic acid are the only agents approved by the US Food and Drug Administration (FDA) for the treatment of PBC.
However, for patients with advanced, end-stage PBC, liver transplantation is still the most effective treatment.
Accordingly, the alternative approaches, such as mesenchymal stem cell (MSC) transplantation, have been suggested as an effective alternative therapy for these patients.
Due to their immunomodulatory characteristics, MSCs are considered as promising therapeutic agents for the therapy of autoimmune liver diseases, including PBC.
In this review, we have summarized the therapeutic potential of MSCs for the treatment of these diseases, emphasizing molecular and cellular mechanisms responsible for MSC-based effects in an animal model of PBC and therapeutic potential observed in recently conducted clinical trials.
We have also presented several outstanding problems including safety issues regarding unwanted differentiation of transplanted MSCs which limit their therapeutic use.
Efficient and safe MSC-based therapy for PBC remains a challenging issue that requires continuous cooperation between clinicians, researchers, and patients.
American Psychological Association (APA)
Arsenijevic, Aleksandar& Harrell, C. Randall& Fellabaum, Crissy& Volarevic, Vladislav. 2017. Mesenchymal Stem Cells as New Therapeutic Agents for the Treatment of Primary Biliary Cholangitis. Analytical Cellular Pathology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1121719
Modern Language Association (MLA)
Arsenijevic, Aleksandar…[et al.]. Mesenchymal Stem Cells as New Therapeutic Agents for the Treatment of Primary Biliary Cholangitis. Analytical Cellular Pathology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1121719
American Medical Association (AMA)
Arsenijevic, Aleksandar& Harrell, C. Randall& Fellabaum, Crissy& Volarevic, Vladislav. Mesenchymal Stem Cells as New Therapeutic Agents for the Treatment of Primary Biliary Cholangitis. Analytical Cellular Pathology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1121719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1121719