Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway
Joint Authors
Lu, Hongsheng
Zhang, Li-qian
Lv, Rong-wei
Qu, Xiang-dong
Chen, Xian-jun
Wang, Ying
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aloesin is an active constituent of the herb aloe vera and plays a crucial role in anti-inflammatory activity, ultraviolet protection, and antibacterium.
We investigated the role and possible mechanisms of aloesin in the cell growth and metastasis of ovarian cancer.
It was found that aloesin inhibited cell viability and cell clonality in a dose-dependent manner.
It arrests the cell cycle at the S-phase and induced apoptosis in SKOV3 cells.
In an in vivo experiment, it was observed that aloesin inhibited tumor growth.
Moreover, it inhibited migration and invasion of cancer in SKOV3 cells.
Interestingly, members from the mitogen-activated protein kinase (MAPK) signaling family became less phosphorylated as the aloesin dose increased.
This suggests that aloesin exerts its anticancer effect through the MAPK signaling pathway.
Our data also highlights the possibility of using aloesin as a novel therapeutic drug for ovarian cancer treatment.
American Psychological Association (APA)
Zhang, Li-qian& Lv, Rong-wei& Qu, Xiang-dong& Chen, Xian-jun& Lu, Hongsheng& Wang, Ying. 2017. Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway. Analytical Cellular Pathology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1121725
Modern Language Association (MLA)
Zhang, Li-qian…[et al.]. Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway. Analytical Cellular Pathology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1121725
American Medical Association (AMA)
Zhang, Li-qian& Lv, Rong-wei& Qu, Xiang-dong& Chen, Xian-jun& Lu, Hongsheng& Wang, Ying. Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway. Analytical Cellular Pathology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1121725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1121725