Cell Therapies in Cardiomyopathy: Current Status of Clinical Trials
Joint Authors
Hao, Ming
Wang, Richard
Wang, Wen
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-17
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Because the human heart has limited potential for regeneration, the loss of cardiomyocytes during cardiac myopathy and ischaemic injury can result in heart failure and death.
Stem cell therapy has emerged as a promising strategy for the treatment of dead myocardium, directly or indirectly, and seems to offer functional benefits to patients.
The ideal candidate donor cell for myocardial reconstitution is a stem-like cell that can be easily obtained, has a robust proliferation capacity and a low risk of tumour formation and immune rejection, differentiates into functionally normal cardiomyocytes, and is suitable for minimally invasive clinical transplantation.
The ultimate goal of cardiac repair is to regenerate functionally viable myocardium after myocardial infarction (MI) to prevent or heal heart failure.
This review provides a comprehensive overview of treatment with stem-like cells in preclinical and clinical studies to assess the feasibility and efficacy of this novel therapeutic strategy in ischaemic cardiomyopathy.
American Psychological Association (APA)
Hao, Ming& Wang, Richard& Wang, Wen. 2017. Cell Therapies in Cardiomyopathy: Current Status of Clinical Trials. Analytical Cellular Pathology،Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1121740
Modern Language Association (MLA)
Hao, Ming…[et al.]. Cell Therapies in Cardiomyopathy: Current Status of Clinical Trials. Analytical Cellular Pathology No. 2017 (2017), pp.1-20.
https://search.emarefa.net/detail/BIM-1121740
American Medical Association (AMA)
Hao, Ming& Wang, Richard& Wang, Wen. Cell Therapies in Cardiomyopathy: Current Status of Clinical Trials. Analytical Cellular Pathology. 2017. Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1121740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1121740