Anti-Myeloperoxidase Antibodies Associate with Future Proliferative Lupus Nephritis
Joint Authors
Olson, S. W.
Lee, J. J.
Poirier, M.
Little, D. J.
Prince, L. K.
Baker, T. P.
Edison, J. D.
Abbott, K. C.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The subclinical pathophysiology of proliferative lupus nephritis (PLN) has not been fully elucidated.
Myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) is associated with PLN, but prediagnostic levels have not been reported.
Methods.
We performed a retrospective case-control Department of Defense Serum Repository (DoDSR) study comparing MPO-ANCA levels in longitudinal prediagnostic serum samples for 23 biopsy confirmed proliferative lupus nephritis (PLN) patients to DoDSR identified age, sex, race, and age of serum matched healthy and SLE without LN disease controls.
We also compared the temporal relationship of MPO-ANCA to anti-double stranded DNA antibodies (dsDNAab).
Results.
A greater proportion of PLN patients had prediagnostic MPO-ANCA levels above ≥3 U/mL and ≥6 U/mL compared to SLE without LN (91% versus 43%, p<0.001; 57% versus 5%, p<0.001, resp.).
In subgroup analysis, the MPO-ANCA threshold of ≥3 U/mL was significant at <1 year (88% versus 39%, p=0.007) and 1–4 years (87% versus 38%, p=0.009) prior to diagnosis.
Statistically significant subclinical MPO-ANCA levels (≥3 U/mL) occurred prior to statistically significant dsDNAab ≥ 3 IU/ml (89% versus 11%, p=0.003).
Conclusions.
Subclinical MPO-ANCA levels could distinguish future PLN from SLE without LN.
MPO-ANCA manifests prior to clinical disease and subclinical dsDNAab to suggest that it may contribute directly to PLN pathogenicity.
American Psychological Association (APA)
Olson, S. W.& Lee, J. J.& Poirier, M.& Little, D. J.& Prince, L. K.& Baker, T. P.…[et al.]. 2017. Anti-Myeloperoxidase Antibodies Associate with Future Proliferative Lupus Nephritis. Autoimmune Diseases،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1121745
Modern Language Association (MLA)
Olson, S. W.…[et al.]. Anti-Myeloperoxidase Antibodies Associate with Future Proliferative Lupus Nephritis. Autoimmune Diseases No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1121745
American Medical Association (AMA)
Olson, S. W.& Lee, J. J.& Poirier, M.& Little, D. J.& Prince, L. K.& Baker, T. P.…[et al.]. Anti-Myeloperoxidase Antibodies Associate with Future Proliferative Lupus Nephritis. Autoimmune Diseases. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1121745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1121745