Frequency and Type of Hepatic and Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus
Joint Authors
Ziaee, Vahid
Alimadadi, Hosein
Tahernia, Leila
Tahghighi, Fatemeh
Amini, Zahra
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Systemic lupus erythematosus (SLE) is a frequent rheumatology disorder among children.
Since hepatic involvement is a common systemic manifestation in lupus, the frequency and type of hepatic involvement were determined in pediatric cases of SLE admitted to Children’s Medical Hospital from 2005 to 2014.
Methods and Patients.
In this observational case-series study, 138 pediatric cases of SLE were admitted in Children’s Medical Center (a pediatric rheumatology referral center in Tehran, Iran) enrolled from 2005 to 2014 and the outcomes, frequency, and type of hepatic involvement were assessed among them.
Results.
Hepatic involvement was reported in 48.55% of total SLE patients.
Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and both enzymes higher than normal upper limits were detected in 8.7%, 5%, and 34.7% of lupus patients, respectively.
Increased level of liver enzymes was categorized as less than 100, between 100 and 1000, and more than 1000 levels in 23.1%, 23.1%, and 2.1% of cases.
The only gastrointestinal involvement in lupus patients contributing to hepatic involvement was gastrointestinal bleeding.
Rising in liver enzymes was detected mostly in lupus patients without gastrointestinal bleeding (52.2% without versus 25.8% with gastrointestinal bleeding, P=0.007).
Conclusion.
Approximately half of the pediatric patients suffering from SLE have hepatic involvement.
No significant correlation was observed between various organs involvement and abnormal level of liver enzymes.
American Psychological Association (APA)
Tahernia, Leila& Alimadadi, Hosein& Tahghighi, Fatemeh& Amini, Zahra& Ziaee, Vahid. 2017. Frequency and Type of Hepatic and Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus. Autoimmune Diseases،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1121752
Modern Language Association (MLA)
Tahernia, Leila…[et al.]. Frequency and Type of Hepatic and Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus. Autoimmune Diseases No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1121752
American Medical Association (AMA)
Tahernia, Leila& Alimadadi, Hosein& Tahghighi, Fatemeh& Amini, Zahra& Ziaee, Vahid. Frequency and Type of Hepatic and Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus. Autoimmune Diseases. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1121752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1121752