GRP78BIPHSPA5 as a Therapeutic Target in Models of Parkinson’s Disease: A Mini Review

Joint Authors

Enogieru, Adaze Bijou
Omoruyi, Sylvester Ifeanyi
Ekpo, O. E.
Hiss, Donavon

Source

Advances in Pharmacological and Pharmaceutical Sciences

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-03-05

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Pharmacology

Abstract EN

Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by selective loss of dopamine neurons in the substantia nigra pars compacta of the midbrain.

Reports from postmortem studies in the human PD brain, and experimental PD models reveal that endoplasmic reticulum (ER) stress is implicated in the pathogenesis of PD.

In times of stress, the unfolded or misfolded proteins overload the folding capacity of the ER to induce a condition generally known as ER stress.

During ER stress, cells activate the unfolded protein response (UPR) to handle increasing amounts of abnormal proteins, and recent evidence has demonstrated the activation of the ER chaperone GRP78/BiP (78 kDa glucose-regulated protein/binding immunoglobulin protein), which is important for proper folding of newly synthesized and partly folded proteins to maintain protein homeostasis.

Although the activation of this protein is essential for the initiation of the UPR in PD, there are inconsistent reports on its expression in various PD models.

Consequently, this review article aims to summarize current knowledge on neuroprotective agents targeting the expression of GRP78/BiP in the regulation of ER stress in experimental PD models.

American Psychological Association (APA)

Enogieru, Adaze Bijou& Omoruyi, Sylvester Ifeanyi& Hiss, Donavon& Ekpo, O. E.. 2019. GRP78BIPHSPA5 as a Therapeutic Target in Models of Parkinson’s Disease: A Mini Review. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1121825

Modern Language Association (MLA)

Enogieru, Adaze Bijou…[et al.]. GRP78BIPHSPA5 as a Therapeutic Target in Models of Parkinson’s Disease: A Mini Review. Advances in Pharmacological and Pharmaceutical Sciences No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1121825

American Medical Association (AMA)

Enogieru, Adaze Bijou& Omoruyi, Sylvester Ifeanyi& Hiss, Donavon& Ekpo, O. E.. GRP78BIPHSPA5 as a Therapeutic Target in Models of Parkinson’s Disease: A Mini Review. Advances in Pharmacological and Pharmaceutical Sciences. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1121825

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1121825