Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium
Joint Authors
Sarfraz, Rai Muhammad
Ali, Muhammad Rizwan
Mahmood, Asif
Khan, Muhammad Usman
Ahmad, Husnain
Qaisar, Muhammad Naeem
Akram, Muhammad Rouf
Source
Advances in Polymer Technology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Current research work was carried out for gastro-protective delivery of naproxen sodium.
Polyethylene glycol-g-poly (methacrylic acid) nanogels was developed through free radical polymerization technique.
Formulation was characterized for swelling behaviour, entrapment efficiency, Fourier transform infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), and Thermal Gravimetric Analysis (TGA), Powder X-ray diffraction (PXRD), Zeta size distribution, and Zeta potential measurements, and in-vitro drug release.
pH dependent swelling was observed with maximum drug release at higher pH.
PXRD studies confirmed the conversion of loaded drug from crystalline to amorphous form while Zeta size measurement showed size reduction.
On the basis of these results it was concluded that prepared nanogels proved an effective tool for gastro-protective delivery of naproxen sodium.
American Psychological Association (APA)
Sarfraz, Rai Muhammad& Akram, Muhammad Rouf& Ali, Muhammad Rizwan& Mahmood, Asif& Khan, Muhammad Usman& Ahmad, Husnain…[et al.]. 2019. Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium. Advances in Polymer Technology،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1122065
Modern Language Association (MLA)
Sarfraz, Rai Muhammad…[et al.]. Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium. Advances in Polymer Technology No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1122065
American Medical Association (AMA)
Sarfraz, Rai Muhammad& Akram, Muhammad Rouf& Ali, Muhammad Rizwan& Mahmood, Asif& Khan, Muhammad Usman& Ahmad, Husnain…[et al.]. Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium. Advances in Polymer Technology. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1122065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1122065