Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium

Joint Authors

Sarfraz, Rai Muhammad
Ali, Muhammad Rizwan
Mahmood, Asif
Khan, Muhammad Usman
Ahmad, Husnain
Qaisar, Muhammad Naeem
Akram, Muhammad Rouf

Source

Advances in Polymer Technology

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-12-29

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Chemistry

Abstract EN

Current research work was carried out for gastro-protective delivery of naproxen sodium.

Polyethylene glycol-g-poly (methacrylic acid) nanogels was developed through free radical polymerization technique.

Formulation was characterized for swelling behaviour, entrapment efficiency, Fourier transform infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), and Thermal Gravimetric Analysis (TGA), Powder X-ray diffraction (PXRD), Zeta size distribution, and Zeta potential measurements, and in-vitro drug release.

pH dependent swelling was observed with maximum drug release at higher pH.

PXRD studies confirmed the conversion of loaded drug from crystalline to amorphous form while Zeta size measurement showed size reduction.

On the basis of these results it was concluded that prepared nanogels proved an effective tool for gastro-protective delivery of naproxen sodium.

American Psychological Association (APA)

Sarfraz, Rai Muhammad& Akram, Muhammad Rouf& Ali, Muhammad Rizwan& Mahmood, Asif& Khan, Muhammad Usman& Ahmad, Husnain…[et al.]. 2019. Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium. Advances in Polymer Technology،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1122065

Modern Language Association (MLA)

Sarfraz, Rai Muhammad…[et al.]. Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium. Advances in Polymer Technology No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1122065

American Medical Association (AMA)

Sarfraz, Rai Muhammad& Akram, Muhammad Rouf& Ali, Muhammad Rizwan& Mahmood, Asif& Khan, Muhammad Usman& Ahmad, Husnain…[et al.]. Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium. Advances in Polymer Technology. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1122065

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1122065