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Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase
Joint Authors
Westera, Liset
Jennings, Alisha M.
Maamary, Jad
Schwemmle, Martin
García-Sastre, Adolfo
Bortz, Eric
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Influenza A viruses (IAV) are evolutionarily successful pathogens, capable of infecting a number of avian and mammalian species and responsible for pandemic and seasonal epidemic disease in humans.
To infect new species, IAV typically must overcome a number of species barriers to entry, replication, and egress, even while virus replication is counteracted by antiviral host factors and innate immune mechanisms.
A number of host factors have been found to regulate the replication of IAV by interacting with the viral RNA-dependent RNA polymerase (RdRP).
The host factor PARP1, a poly-ADP ribosyl polymerase, was required for optimal functions of human, swine, and avian influenza RdRP in human 293T cells.
In IAV infection, PARP1 was required for efficient synthesis of viral nucleoprotein (NP) in human lung A549 cells.
Intriguingly, pharmacological inhibition of PARP1 enzymatic activity (PARylation) by 4-amino-1,8-naphthalimide led to a 4-fold increase in RdRP activity, and a 2.3-fold increase in virus titer.
Exogenous expression of the natural PARylation inhibitor PARG also enhanced RdRP activity.
These data suggest a virus-host interaction dynamic where PARP1 protein itself is required, but cellular PARylation has a distinct suppressive modality, on influenza A viral polymerase activity in human cells.
American Psychological Association (APA)
Westera, Liset& Jennings, Alisha M.& Maamary, Jad& Schwemmle, Martin& García-Sastre, Adolfo& Bortz, Eric. 2019. Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase. Advances in Virology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1122444
Modern Language Association (MLA)
Westera, Liset…[et al.]. Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase. Advances in Virology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1122444
American Medical Association (AMA)
Westera, Liset& Jennings, Alisha M.& Maamary, Jad& Schwemmle, Martin& García-Sastre, Adolfo& Bortz, Eric. Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase. Advances in Virology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1122444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1122444