Cytotoxicity of the Aqueous Extract and Organic Fractions from Origanum majorana on Human Breast Cell Line MDA-MB-231 and Human Colon Cell Line HT-29
Joint Authors
Makrane, Hanane
El Messaoudi, Mouhcine
Benbacer, Laila
Aziz, Mohammed
El Mzibri, Mohamed
Melhaoui, Ahmed
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The toxicity of the aqueous extract of Origanum majorana was tested (5 and 10 g/kg) in albino mice.
No symptoms of toxicity or mortality were observed.
The mice survived being active and healthy during all 14 days of observation.
In addition, the weight measurement of the left and right kidneys, heart, and liver shows no significant difference between the control, 5 g/kg, and 10 g/kg.
All extracts (aqueous, petroleum ether, dichloromethane, ethyl acetate, methanolic, and depleted aqueous extracts) of Origanum majorana tested against both types of cancer cells showed a more pronounced cytotoxic effect against breast cell line MDA-MB-231 than colon cells line HT-29 cells.
The most marked effect is that of the ethyl acetate extract with IC50 30.90 ± 1.39 and 50.11 ± 1.44 (µg/ml), respectively.
HPLC analysis of extracts from Origanum majorana showed that this plant contained polyphenols and flavonoids, which may be responsible for the biological activities found.
American Psychological Association (APA)
Makrane, Hanane& El Messaoudi, Mouhcine& Melhaoui, Ahmed& El Mzibri, Mohamed& Benbacer, Laila& Aziz, Mohammed. 2018. Cytotoxicity of the Aqueous Extract and Organic Fractions from Origanum majorana on Human Breast Cell Line MDA-MB-231 and Human Colon Cell Line HT-29. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1122763
Modern Language Association (MLA)
Makrane, Hanane…[et al.]. Cytotoxicity of the Aqueous Extract and Organic Fractions from Origanum majorana on Human Breast Cell Line MDA-MB-231 and Human Colon Cell Line HT-29. Advances in Pharmacological and Pharmaceutical Sciences No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1122763
American Medical Association (AMA)
Makrane, Hanane& El Messaoudi, Mouhcine& Melhaoui, Ahmed& El Mzibri, Mohamed& Benbacer, Laila& Aziz, Mohammed. Cytotoxicity of the Aqueous Extract and Organic Fractions from Origanum majorana on Human Breast Cell Line MDA-MB-231 and Human Colon Cell Line HT-29. Advances in Pharmacological and Pharmaceutical Sciences. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1122763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1122763