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Antibacterial Activity of Two Flavans from the Stem Bark of Embelia schimperi
Joint Authors
Endale, Milkyas
Melaku, Yadessa
Guyasa, Babe
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Embelia schemperi Vatke is one of the medicinal plants used traditionally for treatment of intestinal tape worm, dysmenorrheal, bacterial, and fungal infections.
Phytochemical screening test of the dichloromethane/methanol (1 : 1) and methanol extracts revealed the presence of phenols, alkaloids, tannins, and flavonoids whereas terpenoids, glycoside, and phytosterols were absent.
Silica gel column chromatographic separation of the methanol extract afforded 3,5,7,3′,4′-pentahydroxyflavan, named epicatechin (1), along with a close flavan derivative (2).
Structures of the compounds were elucidated by spectroscopic techniques (1D and 2D NMR, FTIR, and UV-Vis).
The crude extracts and isolated compounds were screened for in vitro antibacterial activity against strains of Klebsiella pneumoniae, Escherichia coli, Cryptococcus neoformans, Shigella dysentriae, and Staphylococcus aureus.
Epicatechin (1) exhibited comparable antibacterial activity against S.
aureus and E.
coli (15 and 12 mm zone of inhibition, resp.) to that of the control antibiotic gentamicin, with zone of inhibition of 15 and 12 mm, respectively, at a concentration of 20 µg/mL.
American Psychological Association (APA)
Guyasa, Babe& Melaku, Yadessa& Endale, Milkyas. 2018. Antibacterial Activity of Two Flavans from the Stem Bark of Embelia schimperi. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1122782
Modern Language Association (MLA)
Guyasa, Babe…[et al.]. Antibacterial Activity of Two Flavans from the Stem Bark of Embelia schimperi. Advances in Pharmacological and Pharmaceutical Sciences No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1122782
American Medical Association (AMA)
Guyasa, Babe& Melaku, Yadessa& Endale, Milkyas. Antibacterial Activity of Two Flavans from the Stem Bark of Embelia schimperi. Advances in Pharmacological and Pharmaceutical Sciences. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1122782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1122782