Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1,5-Benzodiazepin-2-One
Joint Authors
Alaoui, Katim
El Jemli, Meryem
Nguema Ongone, Terence
Achour, Redouane
El Ghoul, Mostafa
El Ouasif, Latifa
Taghzouti, Khalid
Zellou, Amina
Cherrah, Y.
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of our work is to make a pharmacological study of molecules derived from 4-phenyl-1,5-benzodiazepin-2-one carrying long chains so that they have a structure similar to surfactants, with the benzodiazepine as a hydrophilic head and a carbon chain as a hydrophobic tail.
First, we studied the acute toxicity of the above mentioned 4-phenyl-1,5-benzodiazepin-2-one derivatives.
This study was conducted according to OECD 423 guidelines in female mice and revealed that these compounds are nontoxic.
We then assessed the psychotropic effects of our products on the central nervous system (CNS).
The results obtained show that 4-phenyl-1,5-benzodiazepin-2-one has no sedative effect at therapeutic doses of 100 and 200 mg/kg.
On the other hand, its long-chain derivatives possess them.
Moreover, all these products have no cataleptic and hypnotic effects at the doses studied.
But at 100 mg/kg, these compounds all have the ability to significantly prolong the hypnotic effect of thiopental sodium.
American Psychological Association (APA)
Nguema Ongone, Terence& Achour, Redouane& El Ghoul, Mostafa& El Ouasif, Latifa& Taghzouti, Khalid& El Jemli, Meryem…[et al.]. 2018. Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1,5-Benzodiazepin-2-One. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1122783
Modern Language Association (MLA)
Nguema Ongone, Terence…[et al.]. Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1,5-Benzodiazepin-2-One. Advances in Pharmacological and Pharmaceutical Sciences No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1122783
American Medical Association (AMA)
Nguema Ongone, Terence& Achour, Redouane& El Ghoul, Mostafa& El Ouasif, Latifa& Taghzouti, Khalid& El Jemli, Meryem…[et al.]. Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1,5-Benzodiazepin-2-One. Advances in Pharmacological and Pharmaceutical Sciences. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1122783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1122783