Toward Improving Medication Adherence: The Suppression of Bitter Taste in Edible Taste Films

Joint Authors

Smutzer, Gregory
Cherian, Silvy
Lee, Brian Sang
Tucker, Robin M.
Lee, Kevin

Source

Advances in Pharmacological and Pharmaceutical Sciences

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-06-25

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Pharmacology

Abstract EN

Bitter taste is aversive to humans, and many oral medications exhibit a bitter taste.

Bitter taste can be suppressed by the use of inhibitors or by masking agents such as sucralose.

Another approach is to encapsulate bitter tasting compounds in order to delay their release.

This delayed release can permit the prior release of bitter masking agents.

Suppression of bitter taste was accomplished by encapsulating a bitter taste stimulus in erodible stearic acid microspheres, and embedding these 5 µmeter diameter microspheres in pullulan films that contain sucralose and peppermint oil as masking agents, along with an encapsulated masking agent (sucralose).

Psychophysical tests demonstrated that films which encapsulated both quinine and sucralose produced a significant and continuous sweet percept when compared to films without sucralose microspheres.

Films with both quinine and sucralose microspheres also produced positive hedonic scores that did not differ from control films that contained only sucralose microspheres or only empty (blank) microspheres.

The encapsulation of bitter taste stimuli in lipid microspheres, and embedding these microspheres in rapidly dissolving edible taste films that contain masking agents in both the film base and in microspheres, is a promising approach for diminishing the bitter taste of drugs and related compounds.

American Psychological Association (APA)

Cherian, Silvy& Lee, Brian Sang& Tucker, Robin M.& Lee, Kevin& Smutzer, Gregory. 2018. Toward Improving Medication Adherence: The Suppression of Bitter Taste in Edible Taste Films. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1122795

Modern Language Association (MLA)

Cherian, Silvy…[et al.]. Toward Improving Medication Adherence: The Suppression of Bitter Taste in Edible Taste Films. Advances in Pharmacological and Pharmaceutical Sciences No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1122795

American Medical Association (AMA)

Cherian, Silvy& Lee, Brian Sang& Tucker, Robin M.& Lee, Kevin& Smutzer, Gregory. Toward Improving Medication Adherence: The Suppression of Bitter Taste in Edible Taste Films. Advances in Pharmacological and Pharmaceutical Sciences. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1122795

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1122795