Crude Polysaccharides from Okra Pods (Abelmoschus esculentus) Grown in Indonesia Enhance the Immune Response due to Bacterial Infection
Joint Authors
Wahyuningsih, Sri Puji Astuti
Pramudya, Manikya
Putri, Intan Permata
Winarni, Dwi
Savira, Nadyatul Ilma Indah
Darmanto, Win
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Okra pods were widely consumed by Indonesians to maintain health.
The aim of this study was at investigating the potential of crude polysaccharides from okra pods on immune response in mice infected with Staphylococcus aureus.
Thirty male Balb/C mice were divided into six groups: normal control, negative control, and treatment groups (administration of crude polysaccharides at doses of 25, 50, 75, and 100 mg/kg).
Crude polysaccharides were administrated for fourteen days.
Furthermore, mice were exposed to S.
aureus at the fifteenth day.
Two weeks after the end of treatment, the parameters were measured.
This study showed that crude polysaccharides at a dose of 75 and 100 mg/kg improved phagocytic activity, spleen index, and splenocytes proliferation.
Rising of TNF-α levels was shown in groups treated with crude polysaccharides at doses of 25, 50, and 100 mg/kg.
All treatment groups showed a decreasing level of IL-17.
Crude okra polysaccharides also showed a slight increase in NK cells activity and IFN-γ level.
Thus, crude okra polysaccharides could act as an effective material to enhance immune response including phagocytic activity, spleen index, splenocytes proliferation, and control immune responses through cytokine production.
American Psychological Association (APA)
Wahyuningsih, Sri Puji Astuti& Pramudya, Manikya& Putri, Intan Permata& Winarni, Dwi& Savira, Nadyatul Ilma Indah& Darmanto, Win. 2018. Crude Polysaccharides from Okra Pods (Abelmoschus esculentus) Grown in Indonesia Enhance the Immune Response due to Bacterial Infection. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1122801
Modern Language Association (MLA)
Wahyuningsih, Sri Puji Astuti…[et al.]. Crude Polysaccharides from Okra Pods (Abelmoschus esculentus) Grown in Indonesia Enhance the Immune Response due to Bacterial Infection. Advances in Pharmacological and Pharmaceutical Sciences No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1122801
American Medical Association (AMA)
Wahyuningsih, Sri Puji Astuti& Pramudya, Manikya& Putri, Intan Permata& Winarni, Dwi& Savira, Nadyatul Ilma Indah& Darmanto, Win. Crude Polysaccharides from Okra Pods (Abelmoschus esculentus) Grown in Indonesia Enhance the Immune Response due to Bacterial Infection. Advances in Pharmacological and Pharmaceutical Sciences. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1122801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1122801