Comparison of Oxidative Effects of Two Different Administration Form of Oxybutynin in the Potential Target Tissues
Joint Authors
Kaltalioglu, Kaan
Tugcu-Demiroz, Fatmanur
Acarturk, Fusun
Balabanli, Barbaros
Coskun-Cevher, Sule
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Oxybutynin is an important anticholinergic agent that prevents uncontrolled contractions in the treatment of overactive bladder (OAB).
However, drugs containing oxybutynin have significant side effects such as dry eyes, dry mouth, increased heart rate, constipation, blurred vision, and confusion.
In recent years, new delivery methods for this agent are being searched.
One of them is vaginal delivery.
In this study, we aimed to compare the effects of oxybutynin on oxidative parameters in the potential target tissues of the oral and vaginal delivery.
Female New Zealand white rabbits (n=12) were divided into two groups: oral delivery and vaginal delivery.
The animals were sacrificed 48 h after administration and nitric oxide (NOx), thiobarbituric acid-reactive substances (TBARs), and glutathione (GSH) levels were determined spectrophotometrically in the aorta, salivary gland, and small intestine tissue samples.
Vaginal delivery significantly decreased NOx levels in all tissue samples as compared to oral delivery (p<0.05).
Moreover, it reduced TBARs levels in salivary gland and aorta tissue samples (p<0.05).
In the light on these findings, it can be said that vaginal delivery may decrease the oxidant-induced side effects of oxybutynin as compared to oral delivery.
American Psychological Association (APA)
Kaltalioglu, Kaan& Tugcu-Demiroz, Fatmanur& Acarturk, Fusun& Balabanli, Barbaros& Coskun-Cevher, Sule. 2018. Comparison of Oxidative Effects of Two Different Administration Form of Oxybutynin in the Potential Target Tissues. Advances in Urology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1123028
Modern Language Association (MLA)
Kaltalioglu, Kaan…[et al.]. Comparison of Oxidative Effects of Two Different Administration Form of Oxybutynin in the Potential Target Tissues. Advances in Urology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1123028
American Medical Association (AMA)
Kaltalioglu, Kaan& Tugcu-Demiroz, Fatmanur& Acarturk, Fusun& Balabanli, Barbaros& Coskun-Cevher, Sule. Comparison of Oxidative Effects of Two Different Administration Form of Oxybutynin in the Potential Target Tissues. Advances in Urology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1123028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123028