Pediatric Germ Cell Tumors: A Developmental Perspective
Joint Authors
Pierce, Joshua L.
Frazier, A. Lindsay
Amatruda, James F.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Germ cell tumors (GCTs) arising in infants, children, and adolescents present a set of special challenges.
GCTs make up about 3% of malignancies in children aged 0–18 and nearly 15% of cancers in adolescents.
Epidemiologic and molecular evidence suggests that GCTs in young children likely represent a distinct biologic group as compared to GCTs of older adolescents and adults.
Despite this difference, pediatric GCTs are typically treated with cisplatin-based multiagent regimens similar to those used in adults.
There is evidence that children are particularly vulnerable to late effects of conventional therapy, including ototoxicity, pulmonary abnormalities, and secondary malignancies, motivating the search for molecular targets for novel therapies.
Evidence is accumulating that the genes and mechanisms controlling normal germ cell development are particularly relevant to the understanding of germ cell tumorigenesis.
Perturbations in the epigenetic program of germ cell differentiation, with resulting effects on the regulation of pluripotency, may contribute to the marked histologic variability of GCTs.
Perturbations in the KIT receptor signaling pathway have been identified via next-generation sequencing studies and in genome-wide association studies of testicular cancer susceptibility.
Here, we review these and other biological insights that may fuel further translational and clinical research in childhood GCTs.
American Psychological Association (APA)
Pierce, Joshua L.& Frazier, A. Lindsay& Amatruda, James F.. 2018. Pediatric Germ Cell Tumors: A Developmental Perspective. Advances in Urology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1123034
Modern Language Association (MLA)
Pierce, Joshua L.…[et al.]. Pediatric Germ Cell Tumors: A Developmental Perspective. Advances in Urology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1123034
American Medical Association (AMA)
Pierce, Joshua L.& Frazier, A. Lindsay& Amatruda, James F.. Pediatric Germ Cell Tumors: A Developmental Perspective. Advances in Urology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1123034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123034