Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis
Joint Authors
Ma, Yao
Feng, Xiao-Fei
Yang, Wan-Xia
You, Chong-Ge
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although immunotherapy has progressed in the treatment of bladder cancer, some patients still have poor prognosis.
New therapeutic targets are eager to be discovered to improve the outcomes of bladder cancer.
With the development of high-throughput sequencing and tumor profiling, potential tumor biomarkers were identified.
Through the interpretation of related data from the Cancer Genome Atlas database (TCGA), some key genes have been discovered to drive the development and prognosis of urinary bladder neoplasm.
On account of the success of immunotherapy in many cancer types, we established the relationship between tumor mutation burden and immune microenvironment of bladder cancer and found the changes of several immune cells in this disease.
Based on the understanding of the bladder tumor genome and immune environment, this study is supposed to provide new therapies for the treatment of bladder neoplasm.
American Psychological Association (APA)
Ma, Yao& Feng, Xiao-Fei& Yang, Wan-Xia& You, Chong-Ge. 2019. Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123176
Modern Language Association (MLA)
Ma, Yao…[et al.]. Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1123176
American Medical Association (AMA)
Ma, Yao& Feng, Xiao-Fei& Yang, Wan-Xia& You, Chong-Ge. Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123176