Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-Type Cell Death
Joint Authors
Masum, Abdullah-Al
Hisamatsu, Yosuke
Yokoi, Kenta
Aoki, Shin
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Death receptors (DR4 and DR5) offer attractive targets for cancer treatment because cancer cell death can be induced by apoptotic signal upon binding of death ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with death receptors.
Cyclometalated iridium(III) complexes such as fac-Ir(tpy)3 (tpy = 2-(4-tolyl)pyridine) possess a C3-symmetric structure like TRAIL and exhibit excellent luminescence properties.
Therefore, cyclometalated Ir complexes functionalized with DR-binding peptide motifs would be potent TRAIL mimics to detect cancer cells and induce their cell death.
In this study, we report on the design and synthesis of C3-symmetric and luminescent Ir complex-peptide hybrids (IPHs), which possess cyclic peptide that had been reported to bind DR5.
The results of 27 MHz quartz-crystal microbalance (QCM) measurements of DR5 with IPHs and costaining experiments of IPHs and anti-DR5 antibody, suggest that IPHs bind with DR5 and undergo internalization into cytoplasm, possibly via endocytosis.
It was also found that IPHs induce slow cell death of these cancer cells in a parallel manner to the DR5 expression level.
These results indicate that IPHs may offer a promising tool as artificial luminescent mimics of death ligands to develop a new category of anticancer agents that detect and kill cancer cells.
American Psychological Association (APA)
Masum, Abdullah-Al& Hisamatsu, Yosuke& Yokoi, Kenta& Aoki, Shin. 2018. Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-Type Cell Death. Bioinorganic Chemistry and Applications،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1123200
Modern Language Association (MLA)
Masum, Abdullah-Al…[et al.]. Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-Type Cell Death. Bioinorganic Chemistry and Applications No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1123200
American Medical Association (AMA)
Masum, Abdullah-Al& Hisamatsu, Yosuke& Yokoi, Kenta& Aoki, Shin. Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-Type Cell Death. Bioinorganic Chemistry and Applications. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1123200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123200