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Zebrafish Models of Human Skeletal Disorders: Embryo and Adult Swimming Together
Joint Authors
Carnovali, Marta
Banfi, Giuseppe
Mariotti, Massimo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Danio rerio (zebrafish) is an elective model organism for the study of vertebrate development because of its high degree of homology with human genes and organs, including bone.
Zebrafish embryos, because of the optical clarity, small size, and fast development, can be easily used in large-scale mutagenesis experiments to isolate mutants with developmental skeletal defects and in high-throughput screenings to find new chemical compounds for the ability to revert the pathological phenotype.
On the other hand, the adult zebrafish represents another powerful resource for pathogenic and therapeutic studies about adult human bone diseases.
In fish, some characteristics such as bone turnover, reparation, and remodeling of the adult bone tissue cannot be found at the embryonic stage.
Several pathological models have been established in adult zebrafish such as bone injury models, osteoporosis, and genetic diseases such as osteogenesis imperfecta.
Given the growing interest for metabolic diseases and their complications, adult zebrafish models of type 2 diabetes and obesity have been recently generated and analyzed for bone complications using scales as model system.
Interestingly, an osteoporosis-like phenotype has been found to be associated with metabolic alterations suggesting that bone complications share the same mechanisms in humans and fish.
Embryo and adult represent powerful resources in rapid development to study bone physiology and pathology from different points of view.
American Psychological Association (APA)
Carnovali, Marta& Banfi, Giuseppe& Mariotti, Massimo. 2019. Zebrafish Models of Human Skeletal Disorders: Embryo and Adult Swimming Together. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1123222
Modern Language Association (MLA)
Carnovali, Marta…[et al.]. Zebrafish Models of Human Skeletal Disorders: Embryo and Adult Swimming Together. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1123222
American Medical Association (AMA)
Carnovali, Marta& Banfi, Giuseppe& Mariotti, Massimo. Zebrafish Models of Human Skeletal Disorders: Embryo and Adult Swimming Together. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1123222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123222