Robust Genetic Circuit Design: A Mixed H∞ and IQC Analysis

Abstract EN

This paper considers the problem of designing a genetic circuit which is robust to noise effect.

To achieve this goal, a mixed H∞ and Integral Quadratic Constraints (IQC) approach is proposed.

In order to minimize the effects of external noise on the genetic regulatory network in terms of H∞ norm, a design procedure of Hill coefficients in the promoters is presented.

The IQC approach is introduced to analyze and guarantee the stability of the designed circuit.