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Effect of Periapical Diseases in Development of MRONJ in Immunocompromised Mouse Model
Joint Authors
Zheng, Li Wu
Yu, Ru Qing
Rao, Nian Jing
Wang, Jing Yi
Helm, Alexandra
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
This study aimed to assess the effect of zoledronic acid on an immunocompromised mice model with periapical disease.
Materials and Methods.
Thirty C57BL/6N mice were randomly divided into three groups (N = 10).
All animals were subjected to bilateral ovariectomy (OVX) and then treated with saline (Veh), zoledronic acid (ZA), or concomitant zoledronic acid and dexamethasone (ZA/Dx) for 12 weeks.
Eight weeks after starting drug administration, pulpal exposure was conducted on the lower left first molar.
Four weeks after pulpal exposure, all mice were sacrificed and the mandibles were collected for radiological and histological examinations.
Results.
Microcomputed tomography (μ-CT) examination showed significantly reduced periapical bone resorption in the ZA/Dx group and decreased periodontal bone resorption in both ZA and ZA/Dx groups.
Higher bone mineral density (BMD) and strengthened microstructure were found in ZA and ZA/Dx groups.
More empty lacunae were found in ZA and ZA/Dx groups.
Conclusions.
Apical periodontitis aggravates MRONJ under immunocompromised circumstances.
Concurrent use of ZA and steroids inhibits alveolar bone resorption but increases the risk of developing MRONJ.
American Psychological Association (APA)
Rao, Nian Jing& Yu, Ru Qing& Wang, Jing Yi& Helm, Alexandra& Zheng, Li Wu. 2019. Effect of Periapical Diseases in Development of MRONJ in Immunocompromised Mouse Model. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1123233
Modern Language Association (MLA)
Rao, Nian Jing…[et al.]. Effect of Periapical Diseases in Development of MRONJ in Immunocompromised Mouse Model. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1123233
American Medical Association (AMA)
Rao, Nian Jing& Yu, Ru Qing& Wang, Jing Yi& Helm, Alexandra& Zheng, Li Wu. Effect of Periapical Diseases in Development of MRONJ in Immunocompromised Mouse Model. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1123233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123233