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Interleukin-6 Expression by Hypothalamic Microglia in Multiple Inflammatory Contexts: A Systematic Review
Joint Authors
Bobbo, Vanessa C. D.
Jara, Carlos P.
Mendes, Natália F.
Morari, Joseane
Velloso, Lício A.
Araújo, Eliana P.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Interleukin-6 (IL-6) is a unique cytokine that can play both pro- and anti-inflammatory roles depending on the anatomical site and conditions under which it has been induced.
Specific neurons of the hypothalamus provide important signals to control food intake and energy expenditure.
In individuals with obesity, a microglia-dependent inflammatory response damages the neural circuits responsible for maintaining whole-body energy homeostasis, resulting in a positive energy balance.
However, little is known about the role of IL-6 in the regulation of hypothalamic microglia.
In this systematic review, we asked what types of conditions and stimuli could modulate microglial IL-6 expression in murine model.
We searched the PubMed and Web of Science databases and analyzed 13 articles that evaluated diverse contexts and study models focused on IL-6 expression and microglia activation, including the effects of stress, hypoxia, infection, neonatal overfeeding and nicotine exposure, lipopolysaccharide stimulus, hormones, exercise protocols, and aging.
The results presented in this review emphasized the role of “injury-like” stimuli, under which IL-6 acts as a proinflammatory cytokine, concomitant with marked microglial activation, which drive hypothalamic neuroinflammation.
Emerging evidence indicates an important correlation of basal IL-6 levels and microglial function with the maintenance of hypothalamic homeostasis.
Advances in our understanding of these different contexts will lead to the development of more specific pharmacological approaches for the management of acute and chronic conditions, like obesity and metabolic diseases, without disturbing the homeostatic functions of IL-6 and microglia in the hypothalamus.
American Psychological Association (APA)
Bobbo, Vanessa C. D.& Jara, Carlos P.& Mendes, Natália F.& Morari, Joseane& Velloso, Lício A.& Araújo, Eliana P.. 2019. Interleukin-6 Expression by Hypothalamic Microglia in Multiple Inflammatory Contexts: A Systematic Review. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123302
Modern Language Association (MLA)
Bobbo, Vanessa C. D.…[et al.]. Interleukin-6 Expression by Hypothalamic Microglia in Multiple Inflammatory Contexts: A Systematic Review. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1123302
American Medical Association (AMA)
Bobbo, Vanessa C. D.& Jara, Carlos P.& Mendes, Natália F.& Morari, Joseane& Velloso, Lício A.& Araújo, Eliana P.. Interleukin-6 Expression by Hypothalamic Microglia in Multiple Inflammatory Contexts: A Systematic Review. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123302