The Dosage of the Derivative of Clostridium Ghonii (DCG) Spores Dictates Whether an IFNγIL-9 or a Strong IFNγ Response Is Elicited in TC-1 Tumour Bearing Mice
Joint Authors
Wei, Ming Q.
Ni, Guoying
Wang, Yong
Yuan, Jianwei
Pan, Xuan
Wei, Jou
Liu, Xiaosong
Good, David
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Anaerobic Clostridial spores (CG) cause significant oncolysis in hypoxic tumour microenvironment and result in tumour regression in both animal models and clinical trials.
The immune mediated response plays a critical role in the antitumour effect by the anaerobic spore treatment.
Method.
Human papillomavirus 16 E6/E7 transformed TC-1 tumour bearing mice were intravenously administered with low (1 × 108 CFU/kg) or high dosage (3 × 108 CFU/kg) of Derivative Clostridial spore (DCG).
Results.
Intravenous administration of the derivative of Clostridial ghonii (DCG) spores leads to both tumour and systemic inflammatory responses characterized by increased IFNγ/IL-9 secreting T cells in the spleen and the tumour.
Low numbers of antigen specific T cells (<20/106 spleen cells) in the spleen of the tumour bearing mice are also detected after intravenous DCG delivery.
Interestingly, our results showed that a mixed IL-9/IFNγ secreting T cell response was induced when the tumour bearing mice received a low dose of DCG spore (1 × 108 CFU/kg), while a strong IFNγ response was elicited with a high dosage of DCG spore (3 × 108 CFU/kg).
Conclusion.
The dosage of DCG spore will determine the types of the DCG induced immune responses.
American Psychological Association (APA)
Ni, Guoying& Wang, Yong& Good, David& Yuan, Jianwei& Pan, Xuan& Wei, Jou…[et al.]. 2019. The Dosage of the Derivative of Clostridium Ghonii (DCG) Spores Dictates Whether an IFNγIL-9 or a Strong IFNγ Response Is Elicited in TC-1 Tumour Bearing Mice. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1123319
Modern Language Association (MLA)
Ni, Guoying…[et al.]. The Dosage of the Derivative of Clostridium Ghonii (DCG) Spores Dictates Whether an IFNγIL-9 or a Strong IFNγ Response Is Elicited in TC-1 Tumour Bearing Mice. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1123319
American Medical Association (AMA)
Ni, Guoying& Wang, Yong& Good, David& Yuan, Jianwei& Pan, Xuan& Wei, Jou…[et al.]. The Dosage of the Derivative of Clostridium Ghonii (DCG) Spores Dictates Whether an IFNγIL-9 or a Strong IFNγ Response Is Elicited in TC-1 Tumour Bearing Mice. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1123319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123319