Expression of Toll-Like Receptors (TLR2 and TLR4) in the Eyes of Mice with Disseminated Acanthamoebiasis
Joint Authors
Lanocha-Arendarczyk, Natalia
Kosik-Bogacka, Danuta Izabela
Kot, Karolina
Wojtkowiak-Giera, Agnieszka
Kolasa-Wołosiuk, Agnieszka
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Toll-like receptors (TLRs) play a key role in the innate immune response to numerous pathogens, including Acanthamoeba spp.
The aim of this study was to determine the expression of TLR2 and TLR4 in the eyes of mice following intranasal infection with Acanthamoeba spp.
in relation to the host’s immunological status.
Amoebae used in this study were isolated from the bronchial aspirate of a patient with acute myeloid leukemia (AML) and atypical symptoms of pneumonia.
We found statistically significant differences in the expression of TLR2 and TLR4 in the eye of immunocompetent mice at 8, 16, and 24 days after Acanthamoeba spp.
infection (dpi) compared to control group.
Immunosuppressed mice showed significant differences in the expression of TLR2 at 16 and 24 dpi compared to uninfected animals.
Our results indicate that TLR2 and TLR4 are upregulated in the eyes of mice in response to Acanthamoeba spp.
We suggest that it is possible for trophozoites to migrate through the optic nerve from the brain to the eyes.
The course of disseminated acanthamoebiasis may be influenced by the host’s immunological status, and the observed changes in expression of TLR2 and TLR4 in the host’s organs may indicate the role of these receptors in the pathomechanism of acanthamoebiasis.
American Psychological Association (APA)
Kot, Karolina& Kosik-Bogacka, Danuta Izabela& Lanocha-Arendarczyk, Natalia& Wojtkowiak-Giera, Agnieszka& Kolasa-Wołosiuk, Agnieszka. 2019. Expression of Toll-Like Receptors (TLR2 and TLR4) in the Eyes of Mice with Disseminated Acanthamoebiasis. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123325
Modern Language Association (MLA)
Kot, Karolina…[et al.]. Expression of Toll-Like Receptors (TLR2 and TLR4) in the Eyes of Mice with Disseminated Acanthamoebiasis. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1123325
American Medical Association (AMA)
Kot, Karolina& Kosik-Bogacka, Danuta Izabela& Lanocha-Arendarczyk, Natalia& Wojtkowiak-Giera, Agnieszka& Kolasa-Wołosiuk, Agnieszka. Expression of Toll-Like Receptors (TLR2 and TLR4) in the Eyes of Mice with Disseminated Acanthamoebiasis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123325