Deep Hypothermic Circulatory Arrest Does Not Show Better Protection for Vital Organs Compared with Moderate Hypothermic Circulatory Arrest in Pig Model

Joint Authors

Li, Haiyang
Zhang, Hongjia
Liu, Yang
Wu, Zining
Dai, Lu
Gong, Ming
Lan, Feng
Guan, Xinliang

Source

BioMed Research International

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-04-17

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

Background.

Continued debates exist regarding the optimal temperature during hypothermic circulatory arrest in aortic arch repair for patients with type A aortic dissection.

This study seeks to examine whether the use of moderate hypothermic circulatory arrest in a pig model provides comparable vital organ protection outcomes to the use of deep hypothermic circulatory arrest.

Methods.

Thirteen pigs were randomly assigned to 30 minutes of hypothermic circulatory arrest without cerebral perfusion at 15°C (n = 5), 25°C (n = 5), and a control group (n = 3).

The changes in standard laboratory tests and capacity for protection against apoptosis in different vital organs were monitored with different temperatures of hypothermic circulatory arrest management in pig model to determine which temperature was optimal for hypothermic circulatory arrest.

Results.

There were no significant differences in the capacity for protection against apoptosis in vital organs between 2 groups (p > 0.05, respectively).

Compared with the moderate hypothermic circulatory arrest group, the deep hypothermic circulatory arrest group had no significant advantages in terms of the biologic parameters of any other organs (p > 0.05).

Conclusions.

Compared with deep hypothermic circulatory arrest, moderate hypothermic circulatory arrest is a moderate technique that has similar advantages with regard to the levels of biomarkers of injury and capacity for protection against apoptosis in vital organs.

American Psychological Association (APA)

Liu, Yang& Wu, Zining& Dai, Lu& Li, Haiyang& Gong, Ming& Lan, Feng…[et al.]. 2019. Deep Hypothermic Circulatory Arrest Does Not Show Better Protection for Vital Organs Compared with Moderate Hypothermic Circulatory Arrest in Pig Model. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123338

Modern Language Association (MLA)

Liu, Yang…[et al.]. Deep Hypothermic Circulatory Arrest Does Not Show Better Protection for Vital Organs Compared with Moderate Hypothermic Circulatory Arrest in Pig Model. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1123338

American Medical Association (AMA)

Liu, Yang& Wu, Zining& Dai, Lu& Li, Haiyang& Gong, Ming& Lan, Feng…[et al.]. Deep Hypothermic Circulatory Arrest Does Not Show Better Protection for Vital Organs Compared with Moderate Hypothermic Circulatory Arrest in Pig Model. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123338

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1123338