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Administration of Repetitive Transcranial Magnetic Stimulation Attenuates Aβ1-42-Induced Alzheimer’s Disease in Mice by Activating β-Catenin Signaling
Joint Authors
Chen, Xueyun
Chen, Shu
Liang, Weidi
Ba, Fang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive and painless technique that has been applied for the treatments of diverse neurodegenerative disorders.
In the current study, its anti-Alzheimer’s disease (AD) effect was assessed and the mechanism driving the effect was explored.
The AD symptoms were induced via the intracranial injection of Aβ1-42 in mice and then treated with rTMS of 1 Hz or 10 Hz.
The anti-AD effect of rTMS was assessed by Morris water maze (MWM), histological staining and western blotting.
The results showed that rTMS administrations of both frequencies improved the cognitive function and suppressed neuron apoptosis in AD mice.
Moreover, the treatment also increased the brain BDNF, NGF, and doublecortin levels, which represented the increased viability of neurons by rTMS.
The injection of Aβ1-42 also increased the expressions of p-GSK-3β, p-Tau, and p-β-catenin and suppressed the level of total β-catenin.
After the treatments of rTMS, the level of β-catenin was restored, indicating the activation of β-catenin signaling.
In conclusion, the findings outlined in the current study demonstrated that the anti-AD effect of rTMS was associated with the activation of β-catenin, which would promote the survival of neurons.
American Psychological Association (APA)
Chen, Xueyun& Chen, Shu& Liang, Weidi& Ba, Fang. 2019. Administration of Repetitive Transcranial Magnetic Stimulation Attenuates Aβ1-42-Induced Alzheimer’s Disease in Mice by Activating β-Catenin Signaling. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123351
Modern Language Association (MLA)
Chen, Xueyun…[et al.]. Administration of Repetitive Transcranial Magnetic Stimulation Attenuates Aβ1-42-Induced Alzheimer’s Disease in Mice by Activating β-Catenin Signaling. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1123351
American Medical Association (AMA)
Chen, Xueyun& Chen, Shu& Liang, Weidi& Ba, Fang. Administration of Repetitive Transcranial Magnetic Stimulation Attenuates Aβ1-42-Induced Alzheimer’s Disease in Mice by Activating β-Catenin Signaling. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123351