Insulin Resistance and Cardiovascular Risks in Different Groups of Hemodialysis Patients: A Multicenter Study

Abstract EN

Background.

To investigate the association between insulin resistance (IR) and cardiovascular disease (CVD) risks among hemodialysis patients.

Methods.

We conducted a cross-sectional study between 2013 and 2017, on 384 hemodialysis patients from seven hospital-based-dialysis centers.

HOMA-IR is classified according to median value.

The CVD risks were defined by the K/DOQI Guidelines.

Logistic regression analysis was used.

Results.

Patients’ age was 60.9 ± 11.8, 58.1% men, and 40.3% overweight/obese.

The median of HOMA-IR was 5.4, 82.8% high systolic blood pressure, and 85.7% hyperhomocysteinemia.

In multivariate analysis, IR was significantly associated with higher odds of low high-density lipoprotein cholesterol, high triglyceride, and impaired fasting glucose in groups of normal weight, overweight/obese, nondiabetes, diabetes, and overall sample.

IR linked with elevated high-sensitive C-reactive protein in normal weight patients (odd ratio, OR=2.21, 95% confidence interval, 1.16-4.22, p < .05), with hypoalbuminemia in normal weight patients (OR=8.31, 95% CI, 2.35-29.37, p < .01), in nondiabetes patients (OR=6.59, 95% CI, 1.81-23.95, p < .01), and overall sample (OR=3.07, 1.51-6.23, p < .01).

Conclusions.

The level of IR and prevalence of CVD risks were high in hemodialysis patients.

IR was independently associated with CVD risks.